Adsorption Mechanism of 5-Flourouracil on Different Hydroxyapatite Particles

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The adsorption of the drug 5-Flourouracil (5-FU) on Hydroxyapatite (HAP) particles having different surface conditions is studied at 37°C. Commercial HAP particles, either as received or soaked in citrate solutions are used as drug adsorbents and compared to a third category of HAP particles which consists of granules obtained by spray drying suspensions of HAP nanoparticles previously precipitated in citrate solutions. The adsorbed amount of 5-FU on the HAP particles surface is conditioned by the existing pre-adsorbed citrate ions which contribute to modify the particle surface charge and thus decrease the drug adsorption. However the obtained results also demonstrate that the particle surface charge is not the unique factor to govern the 5-FU adsorption on the HAP particles surface.

Info:

Periodical:

Materials Science Forum (Volumes 514-516)

Edited by:

Paula Maria Vilarinho

Pages:

1103-1110

DOI:

10.4028/www.scientific.net/MSF.514-516.1103

Citation:

C. Santos et al., "Adsorption Mechanism of 5-Flourouracil on Different Hydroxyapatite Particles", Materials Science Forum, Vols. 514-516, pp. 1103-1110, 2006

Online since:

May 2006

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$38.00

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