During the last decade, some major improvements have been achieved concerning the evaluation of new types of materials suitable for aeronautical components exposed to severe operational conditions, such as turbine disks. Due to their outstanding mechanical properties, nickel base superalloys assumed a preferential position when compared with other conventional metallic alloys, benefiting from both their superior fatigue strength and high temperature behaviour. However, these alloys evince a high sensibility concerning possible defects that can arise due to certain types of loading, such as porosities and cavities associated with creep-fatigue at high temperatures. The present paper compiles some experimental results obtained for two types of recent nickel base superalloys. Some fatigue tests were performed using two configurations of these materials: a set of Udimet 720Li specimens (CT geometry) and a set of RR1000 specimens (CN geometry). A maximum temperature of 650°C was considered in both types of materials. The mechanical properties of these alloys were inferred via typical FCGR parameters, such as da/dN vs K curves, complemented with detailed analyses of the cracking mechanisms based on SEM observations. Finally, some metallographic characterization tests were carried out in order to determine the average grain size of these PM alloys and to confirm the presence of important microstructural constituents that can influence the overall fatigue performance of these materials.