Evaluation of Cytotoxic Activity of d-Metal Complexes with Hydrazone Ligands
Cytotoxic activity of four series of coordinated complexes of Zn(II) and Fe(II) with hydrazone/hydrazide ligands against HeLa and B16 cells was evaluated. The ligands N’,N'2- bis[(1E)-1-(2-pyridyl)ethylidene]ethanedihydrazide (H2L1) and N’,N'2-bis[(1E)-1-(2-pyridyl) ethylidene]propanedihydrazide (H2L2) and their Zn(II) complexes showed IC50 values in the low micromolar range, while the other ligands and complexes were less active or inactive.
Dragan P. Uskokovic, Slobodan K. Milonjic and Dejan I. Rakovic
M. Lazić, S. Radulović, T. R. Todorović, D.M. Sladić, Ž. Tešić, K.K. Andjelković, "Evaluation of Cytotoxic Activity of d-Metal Complexes with Hydrazone Ligands", Materials Science Forum, Vol. 518, pp. 513-518, 2006