Evaluation of Cytotoxic Activity of d-Metal Complexes with Hydrazone Ligands

Abstract:

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Cytotoxic activity of four series of coordinated complexes of Zn(II) and Fe(II) with hydrazone/hydrazide ligands against HeLa and B16 cells was evaluated. The ligands N’,N'2- bis[(1E)-1-(2-pyridyl)ethylidene]ethanedihydrazide (H2L1) and N’,N'2-bis[(1E)-1-(2-pyridyl) ethylidene]propanedihydrazide (H2L2) and their Zn(II) complexes showed IC50 values in the low micromolar range, while the other ligands and complexes were less active or inactive.

Info:

Periodical:

Edited by:

Dragan P. Uskokovic, Slobodan K. Milonjic and Dejan I. Rakovic

Pages:

513-518

DOI:

10.4028/www.scientific.net/MSF.518.513

Citation:

M. Lazić et al., "Evaluation of Cytotoxic Activity of d-Metal Complexes with Hydrazone Ligands", Materials Science Forum, Vol. 518, pp. 513-518, 2006

Online since:

July 2006

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$35.00

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