Evaluation of Cytotoxic Activity of d-Metal Complexes with Hydrazone Ligands


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Cytotoxic activity of four series of coordinated complexes of Zn(II) and Fe(II) with hydrazone/hydrazide ligands against HeLa and B16 cells was evaluated. The ligands N’,N'2- bis[(1E)-1-(2-pyridyl)ethylidene]ethanedihydrazide (H2L1) and N’,N'2-bis[(1E)-1-(2-pyridyl) ethylidene]propanedihydrazide (H2L2) and their Zn(II) complexes showed IC50 values in the low micromolar range, while the other ligands and complexes were less active or inactive.



Edited by:

Dragan P. Uskokovic, Slobodan K. Milonjic and Dejan I. Rakovic




M. Lazić et al., "Evaluation of Cytotoxic Activity of d-Metal Complexes with Hydrazone Ligands", Materials Science Forum, Vol. 518, pp. 513-518, 2006

Online since:

July 2006




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