Problems for load carrying elements reside mainly in buckling, embrittlement and corrosion. These problems can be mainly solved by introduction of composite materials of a sandwich type. These materials ally lightness, rigidity and resistance to the corrosion. For the design of a large number of applications, static and cyclic properties are necessary. In this paper, first static and fatigue tests on four points bending of four types sandwich panels have been performed. Load/displacement and S-N fatigue curves are presented and analysed. Fatigue failure and damage modes are observed with an electronic microscope and are discussed. Numerical simulation applied to the static tests is compared to the experimental results. The second is to address such fatigue behaviour by using a damage model and check it by experimentation. This fatigue damage model is based on stiffness degradation, which is used as a damage indicator. Four non-linear cumulative damage models derived from the chosen stiffness degradation equation are examined with assumption of linear Miner’s damage summation. Predicted results are compared with available experimental data.