Study of Calcium Phosphate Deposition on Porous Titanium Samples


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Surgical implant coatings and grafts for tissue replacement have been made by porous surface materials to improve the implant to bone attachment. In this work, porous titanium samples were produced via powder metallurgy techniques and submitted to the biomimetic process in order to enhance its osteoconductivity. This process allows a nucleation and growth of a calcium phosphate film which makes a chemical bond with titanium. Therefore, it avoids the looseness of this film from substrate. The samples were chemically treated, heat treated at different temperatures and soaked into a modified body fluid solution (mSBF) during periods of 2 and 7 days. Samples with and without pretreatments and not soaked in mSBF were used as controls. SEM and EDX analyses detected a calcium phosphate phase on the sample surfaces treated at 400°C and 600°C and soaked in mSBF for 2 and 7 days. The results demonstrated the potential of the methodology applied for obtaining a bonelike apatite film on porous titanium samples processed by powder metallurgy.



Materials Science Forum (Volumes 530-531)

Edited by:

Lucio Salgado and Francisco Ambrozio Filho




W. Silva de Medeiros et al., "Study of Calcium Phosphate Deposition on Porous Titanium Samples", Materials Science Forum, Vols. 530-531, pp. 569-574, 2006

Online since:

November 2006




[1] R. M. German. Powder Metallurgy Science, 2 nd Ed. MPIF, (1994).

[2] M. Takemoto, S. Fujibayashi, M. Neo, J. Suzuki, T. Kokubo, T. Nakamura. Biomaterials 26 (2005) pp.6014-6023.


[3] H. Q. Nguyen, D. A. Deporter, R. M. Pilliar, N. Valiquette, R. Yakubovich. Biomaterials 25 (2004) pp.865-876.

[4] L. Gan, J. Wang, A. Tache, N. Valiquette, D. Deporter, R. M. Pilliar. Biomaterials 25 (2004) pp.5313-5321.

[5] M. Wei, M. Uchida, H. M. Kim, T. Kokubo, T. Nakamura. Biomaterials 23 (2002) pp.167-172.

[6] M. C. Andrade, M. R. Filgueiras, T. Ogasawara. Journal of the European Ceramic Society 22 (2002) pp.505-510.

[7] W. Q. Yang, T. Nakamura, K. Kawanabe, S. Nishigochi, M. Oka, T. Kokubo. Biomaterials (1997) pp.1185-1190.

[8] L. Jonàsova, F. A. Müller, A. Helebrant, J. Strnad, P. Greil. Biomaterials 25 (2004) 1187- 1194.


[9] H. M. Kim, H. Takadama, T. Kokubo, N. Shigeru, T. Nakamura. Biomaterials 21 (2000) pp.353-358.

[10] S. Nishiguchi, N. Takashi, K. Masahiko, K. Hyun-Min, F. Miyaji, T. Kokubo. Biomaterials 20 (1999) pp.491-500.


[11] S. Nishiguchi, H. Kato, H. Fujita, M. Oka, H. M. Kim, T. kokubo, T. Nakamura. Biomaterials 22 (2001) pp.2525-2533.


[12] S. Fujibayashi, N. Masashi, H. M. Kim, T. Kokubo, T. Nakamura. Biomaterials 25 (2004) pp.443-450.

[13] T. Kokubo. Acta Metallurgica vol. 46 (7) pp.2519-2527, (1998).

[14] P. Habibovic, F. Barrère, C. A. Blitterswijk, K. Groot, P. Layrolle. Journal of the American Ceramic Society 85 (3) pp.517-522, (2002).


[15] M. V. de Oliveira, L. C. Pereira, C. A. A. Cairo. PTECH03, Fourth International Latin American Conference on Powder Metallurgy, Guarujá, SP, Brazil, November 19, (2003).

[16] M. C. Andrade. D. Sc. Thesis - Metallurgical and Materials Engineering Program, PEMM/COPPE/UFRJ, Rio de Janeiro, Brazil, February (1999).

[17] J. F. de Oliveira. D. Sc. Thesis - Metallurgical and Materials Engineering Program, PEMM/COPPE/UFRJ, Rio de Janeiro, Brazil, March (2003).