Fabrication of Fiber-Reinforced CPC Composite Artificial Bone by RP/RT


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Self-hardening calcium phosphate cement (CPC) could not be used to repair a large segmental defect in a load-bearing bone because of its brittleness and weak shock resistance as well as ultra-minute pores. Recent studies incorporated fibers into CPC to improve its strength. A novel approach by rapid prototyping and rapid tool technique (RP/RT) was used in this paper to fabricate fibre-reinforced CPC composite artificial bone. The subsequent mechanical experiments demonstrated that the compressive strength of the CPC-fiber artificial bone was 24MPa, which was significantly higher than 6MPa for CPC control without fiber. And in-vivo experiment about canine radius repair proved that the implanted CPC-fiber artificial bone enabled to provide short-time reinforced mechanical strength, while the degraded fibers created new macropores for new tissue ingrowth. In summary, the CPC-fiber artificial bone may facilitate bone ingrowth and its four times increase in strength may help extend the use of CPC to larger bone repairs in moderately stress-bearing locations.



Materials Science Forum (Volumes 532-533)

Edited by:

Chengyu Jiang, Geng Liu, Dinghua Zhang and Xipeng Xu




Q. Lian et al., "Fabrication of Fiber-Reinforced CPC Composite Artificial Bone by RP/RT", Materials Science Forum, Vols. 532-533, pp. 745-748, 2006

Online since:

December 2006




[1] P. Zhao, K.N. Sun and G.G. Zhu: J. Chin. Cera. Society, Vol. 33 (2005), pp.32-35.

[2] H.K.H. Xu and B.Q. Janet: Biomaterials, Vol. 23 (2002), pp.193-202.

[3] H.K.H. Xu and G.S. Carl: J. Ortho. Research, Vol. 22 (2004), pp.535-543.

[4] H.K.H. Xu and G.S. Carl: Biomaterials, Vol. 26 (2005), pp.1337-1348.

[5] M.N.V.R. Kumar: Reactive & Functional Polymers, Vol. 46 (2000), pp.1-27.

[6] E. Ohashi and I. Karube: J. Biotechnology, Vol. 40 (1995), pp.13-19.

[7] L. Leroux, Z. Hatim, M. Freche and J.L. Lacout: Bone, Vol. 25 (1999), pp. 31S-34S.

DOI: https://doi.org/10.1016/s8756-3282(99)00130-1