Biofunctional Hybrid of Titanium with Polymers
Application of metals will be expanded to new medical devices, scaffold for tissue engineering, artificial organs, etc. with the addition of biofunction. Therefore, immobilization or combination of functional polymers to metals is significant subject for the application of metals to biofunctional materials and sensors. Metal-polymer hybrid materials are promising biomaterials future, especially for artificial organs. To form metal-polymer hybrid for biomedical devices, two techniques are predominant according to the purpose: Immobilization of biofunctional polymers to metals and bonding of biopolymers with metals. In the first case, poly(ethylene glycol: PEG) is a biofuctional molecule on which adsorption of proteins is inhibited. Control of immobilization mode of PEG modified with NH2 to titanium surface by electrodeposition is feasible and the adsorption of proteins is inhibited by the deposited PEG. This technique could be applied to all metallic materials. In the other case, we attempted to form a composite of titanium with segmentated polyurethane (SPU) thorough silane-coupling agent (γ-MPS). This composite material is applied to texture of titanium covered by SPU as artificial organs.
T. Chandra, K. Tsuzaki, M. Militzer , C. Ravindran
T. Hanawa et al., "Biofunctional Hybrid of Titanium with Polymers", Materials Science Forum, Vols. 539-543, pp. 563-566, 2007