A Window of Opportunity: Designing Carbon Nanomaterials for Environmental Safety and Health


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Carbon nanomaterials are among the best known and most promising products of the nanotechnology movement. Some early studies suggest that fullerenes and nanotubes may pose significant health risks, and this has given rise to an emerging literature on carbon nanotoxicology. This young field has now begun to yield insight into toxicity mechanisms and the specific material features involved in those mechanisms. This paper explores the potential to alter those material features through post-processing or reformulation with the goal of reducing or eliminating carbon nanomaterial health risks. The paper emphasizes the important roles of metal content and bioavailability, carbon surface chemistry, and nanomaterial aggregation state. The nanotechnology movement has been given a unique "window of opportunity" to systematically investigate the toxicity of nanotechnology products and to develop ways to manage health risks before large scale manufacturing becomes widespread.



Materials Science Forum (Volumes 544-545)

Edited by:

Hyungsun Kim, Junichi Hojo and Soo Wohn Lee




L. Guo et al., "A Window of Opportunity: Designing Carbon Nanomaterials for Environmental Safety and Health", Materials Science Forum, Vols. 544-545, pp. 511-516, 2007

Online since:

May 2007


[1] S.K. Smart, A.I., Cassady, G.Q. Lu, and D.J. Martin, Carbon 44 (2006) p.1034.

[2] R. Hurt, M. Monthioux A. Kane, Carbon 2006 44 1028-1033.

[3] A. Huczko, H. Lange, E. Calko, H., Grubek-Jaworska, P. Droszcz, Full. Sci Tech 9 (2001), p.251.

DOI: https://doi.org/10.1081/fst-100102973

[4] C. Lam, J.T. James, R. McCluskey, R. Hunter, Toxicol Sci 77 (2004) p.126.

[5] D. Cui, F. Tian, C.S. Ozkan, M., Wang, H., Gao, Toxicol Lett 155 (2005) p.73.

[6] N.W.S. Kam, T.C. Jessop, P.A. Wender, and H. Dai, J Am Chem Soc 126, (2004) p.6850.

[7] E. Oberdörster, Environ Health Perspect, 112 (2004) p.1058.

[8] C.M. Sayes, J.D. Fortner, W. Guo, D. Lyon, A.M. Boyd, K. D. Ausman, Y.J. Tao, B. Sitharaman, L.J. Wilson, J.B. Hughes, J.L. West, V.L. Colvin, Nano Letters, 4 (2004) p.1881.

DOI: https://doi.org/10.1021/nl0489586

[9] J. L. Fortner, DY, C. M. Sayes, A. M. Boyd, J. Falkner, E. Hotze, L. Alemany, Y. Tao, K. Ausman, V. Colvin and J. Hughes, Environ Sci. Technol 39 (2005) P. 4307.

DOI: https://doi.org/10.1021/es048099n

[10] E. Oberdörster, S. Zhu, T M. Blickley, P. McClellan-Green, M.L. Haasch, Carbon 44 (2006) p.1112.

[11] A.R. Oller, M. Costa, G. Oberdorster, Tox. Appl. Pharmacol. 143 (1997) p.152.

[12] M. Costa and H.H. Mollenhauer, Science, 209 (1980) p.515.

[13] E.T. Snow and M. Costa, Environmental and Occupational medicine; Lippincott-Raven Publishers: Philadelphia Chapt 75 p.1057 (1998).

[14] Q. Zhang T. Kusaka, K. Sato Y. Mo, M. Fukuda, K. Donaldson, J. Occup. Health 40 (1998) 171.

[15] F. Tao, B. Gonzalez-Flecha, L. Kobzik, Free Rad. Biol. & Med. 35 (2003) p.327.

[16] J.A. Hardy and A.E. Aust, Chem. Rev. 95 (1995) p.97.

[17] A.A. Shvedova, et al. J. Toxicol. Environ. Health., Part A 66 (2003) p. (1909).

[18] K. Donaldson, R. Aitken, L. Tran, V. Stone, R. Duffin, G. Forrest, A. Alexander Toxicol. Sci. 91 (2006) p.5.

[19] B. Fubini and C.O. Areán, Chem. Soc. Rev. 28 (1999) p.373.

[20] A. Shukla, et al. Free Rad. Biol. & Med. 34 (2003) p.1117.

[21] S. Hirano, N. Kodama, K. Shibata, K.T. Suzuki, Toxicol. Appl. Pharmacology, 104 (1990) p.301.

[22] K. Marubashi, S. Hirano, Suzuki K.T., Toxicology Letters, 99 (1998) 43.

[23] Y. Nakamura, Y. Tsumura, Y. Tonogai, T. Shibata, Y. Ito, Fund. Appl. Toxicology 37 (1997) 106.

[24] D. Schubert, R. Dargusch, J. Raitano, S-W. Chan, Biochem. Biophys. Res. Comm. 342 (2006) 86.

[25] J.L. Domingo, Toxicology and Environmental Health, 42 (1994) p.123.

[26] D.F. Lison, Chapter 73 in Environmental and Occupational Medicine, Third Edition (W.N. Rom, Ed. ), Lippincott-Raven, Philadelphia, (1998).

[27] N. Lombaert, M. De Boeck, I. Decordier, E. Cundari,. D. Lison,. M. Kirsh-Volders, Toxicology Letters 154 (2004) p.23.

[28] Q. Zhang, Y. Kusaka, K. Sato, J. Toxicology Envir. Health Part A 53 (1998) 423.

[29] K. Jian, I. Kulaots, A. Yan, G.P. Crawford, R.H. Hurt, Carbon, 44 (2006) 2102.

[30] A. Yan, X. Cheng, I. Kulaots, B.W. Sheldon, R.H. Hurt, Controlling water contact angle on carbon surfaces from 5 to 167 degrees, Carbon, in press, (2006).

DOI: https://doi.org/10.1016/j.carbon.2006.08.004

[31] H. Dumortier, S. Lacotte, G. Pastorin, R. Marega, W. Wu, D. Bonifazi, J. Briand, M. Prato, S. Muller, A. Bianco, Nano Letters 6 (2006) 1522-1528.

DOI: https://doi.org/10.1021/nl061160x