Preparation of Nano-Hydroxyapatite/Polyamide6 Composite Porous Scaffold for Bone Tissue Engineering


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Scaffold in bone tissue engineering must have a three-dimensional (3-D) interconnected porous structure acting as a template for bone tissue regeneration, and material fabricating the scaffold must be biocompatible and can provide structural support during bone growth and remodeling at the same time. In this paper, a method of phase separation and particle leaching combined (PS/PL) was used to prepare porous scaffold of nano-hydroxyapatite and polyamide6 (n-HA/PA6) composite. The results show that the scaffold prepared by PS/PL has not only interconnected macropores of 100~300 μm, but also micropores on the walls of macropores, and PS/PL scaffold is more interconnective in compare with phase separation (PS) scaffold. When the porosity of the scaffold is about 79%, its compressive strongth is about 3.27 MPa, that is similar to the human cancellous bone(2~10MPa). Ethanol has some effect on hydrogen bonds, but fabricating method will not change the chemical component of the composite. The porous scaffold is prospect for bone tissue engineering.



Materials Science Forum (Volumes 544-545)

Edited by:

Hyungsun Kim, Junichi Hojo and Soo Wohn Lee




L. Cheng et al., "Preparation of Nano-Hydroxyapatite/Polyamide6 Composite Porous Scaffold for Bone Tissue Engineering", Materials Science Forum, Vols. 544-545, pp. 793-796, 2007

Online since:

May 2007




[1] Karen J.L. Burg, Scott Porter, James F. Kellam: Biomaterials 21 (2000) 2347-2359.


[2] Hassna R.R. Ramay, M. Zhang. : Biomaterials, 25 (2004)5171-5180.

[3] Wei Jie, Li Yubao : Eeropean Polymer Journal, 40 (2004) 509-515.

[4] Zuo Yi, Li Yubao, Wei Jie, Han Jing, Xu Feng-lan : Journal of functional materials (Chinese) 2004. (435)513-516.

[5] Li Yubao, Zuo Yi, Wei Jie : Patent, China, CNZL 200310111033. 5.

[6] Cerroni,L.; Filocamo, R.; Fabbri,M.; Piconi,C.; Caropreso,S.; Cond,S. G : Biomolecular Engineering. 19 (2002) 119-124.


[7] Guobao Wei, Peter X. Ma : Biomaterials 25 (2004) 4749-4757.

[8] Peng Zhihan, Shi Zupei : Handbook of plastic industry (Chinese)2001, 124-125.