Preparation of Nano-Hydroxyapatite/Polyamide6 Composite Porous Scaffold for Bone Tissue Engineering

Abstract:

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Scaffold in bone tissue engineering must have a three-dimensional (3-D) interconnected porous structure acting as a template for bone tissue regeneration, and material fabricating the scaffold must be biocompatible and can provide structural support during bone growth and remodeling at the same time. In this paper, a method of phase separation and particle leaching combined (PS/PL) was used to prepare porous scaffold of nano-hydroxyapatite and polyamide6 (n-HA/PA6) composite. The results show that the scaffold prepared by PS/PL has not only interconnected macropores of 100~300 μm, but also micropores on the walls of macropores, and PS/PL scaffold is more interconnective in compare with phase separation (PS) scaffold. When the porosity of the scaffold is about 79%, its compressive strongth is about 3.27 MPa, that is similar to the human cancellous bone(2~10MPa). Ethanol has some effect on hydrogen bonds, but fabricating method will not change the chemical component of the composite. The porous scaffold is prospect for bone tissue engineering.

Info:

Periodical:

Materials Science Forum (Volumes 544-545)

Edited by:

Hyungsun Kim, Junichi Hojo and Soo Wohn Lee

Pages:

793-796

DOI:

10.4028/www.scientific.net/MSF.544-545.793

Citation:

L. Cheng et al., "Preparation of Nano-Hydroxyapatite/Polyamide6 Composite Porous Scaffold for Bone Tissue Engineering", Materials Science Forum, Vols. 544-545, pp. 793-796, 2007

Online since:

May 2007

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Price:

$35.00

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