Fabrication of n-HA/CS Porous Scaffold Carrying Ampicillin-Loaded Microspheres


Article Preview

In the paper, ampicillin-loaded alginate(ALG) microspheres covered with chitosan (CS) were firstly prepared by emulsification/internal gelation method. These microspheres were mixed with n-HA/CS composite and then were fabricated into porous scaffold carrying micropheres by gas-foaming together with phase-separation. their properties were characterized by the methods of scanning electronic microscopy (SEM), X-ray diffraction (XRD), infrared spectroscopy (IR) and inversed microscope. The drug releasing rate and entrapment efficiency were tested by spectrophotometry at 203 nm. The results show that the porous scaffold carrying microspheres has good property of slow drug releasing rate. The research will offer a new kind of degradable porous scaffold with good property of controlled drug release for bone or cartilage repairing.



Materials Science Forum (Volumes 544-545)

Edited by:

Hyungsun Kim, Junichi Hojo and Soo Wohn Lee




P. J. Shi et al., "Fabrication of n-HA/CS Porous Scaffold Carrying Ampicillin-Loaded Microspheres", Materials Science Forum, Vols. 544-545, pp. 941-944, 2007

Online since:

May 2007




[1] V.R. Sinha, A.K. Singla, S. Wadhawan, R. Kumria, K. Bansal, S. Dhawan: International Journal of Pharmaceutics: 274 (2004) 1-33.

DOI: https://doi.org/10.1016/j.ijpharm.2003.12.026

[2] Libo Yang, James S. Chu, Joseph A. Fix: International Journal of Pharmaceutics: 235 (2002) 1-15.

[3] Alekha K. Dash and Greggrey C. Cudworth II: Journal of Pharmacological and Toxicological Methods: 40, 1-12(1998).

[4] Anil K. Anal, Willem F. Stevens: International Journal of Pharmaceutics: 312 (2006) 166-173.

[5] Zhang R, Ma PX. J Biomed Mater Res 1999; 44: 446-455.

[6] P. Giunchedi, I. Genta, B. Conti, R.A. A Muzzarelli, U. Conte: Biomaterials: 19 (1998) 157-161.

[7] C.C. Ribeiro, C.C. Barrias, M.A. Barbosa: Biomaterials: 25 (2004) 4363-4373. b a.