Fabrication of n-HA/CS Porous Scaffold Carrying Ampicillin-Loaded Microspheres
In the paper, ampicillin-loaded alginate(ALG) microspheres covered with chitosan (CS) were firstly prepared by emulsification/internal gelation method. These microspheres were mixed with n-HA/CS composite and then were fabricated into porous scaffold carrying micropheres by gas-foaming together with phase-separation. their properties were characterized by the methods of scanning electronic microscopy (SEM), X-ray diffraction (XRD), infrared spectroscopy (IR) and inversed microscope. The drug releasing rate and entrapment efficiency were tested by spectrophotometry at 203 nm. The results show that the porous scaffold carrying microspheres has good property of slow drug releasing rate. The research will offer a new kind of degradable porous scaffold with good property of controlled drug release for bone or cartilage repairing.
Hyungsun Kim, Junichi Hojo and Soo Wohn Lee
P. J. Shi et al., "Fabrication of n-HA/CS Porous Scaffold Carrying Ampicillin-Loaded Microspheres", Materials Science Forum, Vols. 544-545, pp. 941-944, 2007