High-temperature deformation behavior and microstructural evolution process of ELI Ti-6Al-4V alloy having martensite microstructure were investigated with the variation of strain, strain rate and temperature. A series of hot compression tests was carried out isothermally for martensite microstructure at the true strain range of 0.6 to 1.4, strain rate range of 10-3 s-1 to 1 s-1 and temperature range of 700 oC to 950 oC. The processing maps for martensite microstructures were constructed on the basis of dynamic materials model (DMM). At the strain rate higher than 10-2 s-1 and the temperature lower than 750 oC regions of flow instability such as adiabatic shear band and micro-cracking were observed. Also, after imposing an effective strain of ≈ 1.4, deformed microstructure showed the significant kinking/bending behavior of lamellae resulting in the dynamic globularization associated with the fragmentation of beta-phase. The effects of strain, strain rate and temperature for dynamic globularization were discussed based on the microstructure and efficiency of power dissipation.