Ti2AlNb orthorhombic alloys exhibit great potential as advanced aerospace and structural materials serviced at elevated temperature. In this paper, pre-heat treatment of as-received hot rolling Ti-22Al-25Nb alloy was conducted. Fine, stable and equiaxed grain structure was obtained by the pre-heat treatment. The volume fraction of B2 increased when annealing at 980°C. The Ti-22Al-25Nb alloy showed characteristics of superplastic deformation when tested at 960°C. Maximum elongation of 280% has been obtained at strain rate of 1.0×10-4s-1.