The Stabilizer Influence on Morphological Characteristics of Poly-(DL-Lactide-Co-Glycolide) Nanospheres


Article Preview

Copolymer poly(D,L-lactide-co-glycolide) is used for obtaining the systems for controlled delivery of medicaments. Its specific characteristics make it suitable for various researches where its synthesis is performed in different ways. Using the system for controlled delivery of medicaments, an equal concentration of the medicament is achieved in the body throughout an extended period of time and it has advantages over the conventional methods. In this paper we present a new solvent/non-solvent chemical method for obtaining DLPLG nanospheres. In the experiment various stabilizers were used in order to examine their influence on morphological characteristics of DLPLG particles. The samples were characterized by Infrared Spectroscopy (IR), Differential Scanning Calorimetry (DSC), Scanning Electron Microscopy (SEM) and Stereological analysis.



Edited by:

Dragan P. Uskoković, Slobodan K. Milonjić and Dejan I. Raković




M. Stevanović et al., "The Stabilizer Influence on Morphological Characteristics of Poly-(DL-Lactide-Co-Glycolide) Nanospheres", Materials Science Forum, Vol. 555, pp. 447-452, 2007

Online since:

September 2007




[1] B.D. Ratner, A.S. Hoffman, F.J. Schoen and J.E. Lemons, Eds.: An Introduction to Biomaterials (Elsevier Inc. 2004).

[2] M. Radić, N. Ignjatović, Z. Nedić, M. Mitrić, D. Miličević and D. Uskoković: Mater. Sci. Forum Vol. 494 (2005), p.537.


[3] J.M. Anderson and M.S. Shive: Advanced Drug Delivery Reviews Vol. 28 (1997), p.5.

[4] M.M. Stevanović, B. Jordović and D.P. Uskoković: Journal of Microencapsulation, submitted.

[5] T. Yokoyama and C.C. Huang: KONA Vol. 23 (2005), p.7.

[6] M. Stevanović, N. Ignjatović, B. Jordović and D. Uskoković: Journal of Materials Science: Materials in Medicine, (2006), accepted.

[7] J. Vandervoort and A. Ludvig: International Journal of Pharmaceutics Vol. 238 (2002), p.77.

[8] S. Feng and G. Huang: Journal of Controlled Release Vol. 71 (2001), p.53.

[9] E.E. Underwood: Quantitative stereology (A. Wesley, M.A. Reading, 1969), p.330.

[10] H. Exner and H. Hougardy: Quantitative image analysis of microstructures (DGM informazions-Gesellschaft Gmbh Verlag, 1988).

[11] M. Kiremitci-Gumusderelioglu and G. Deniz: Turk J. Chem. Vol. 23 (1999), p.153.