Polymer hydrogels have many different functions in the field of tissue engineering and medicine. Modification of 2-hydroxy-ethyl-methacrylate (HEMA) and 2-ethyl-oxy-ethylmethacrylate (EOEMA) by plasma treatment performed in Ar atmosphere at RT for 0-400 s was studied using different techniques. Sample ablation was determined by gravimetry, surface wettability and aging by goniometry, chemical structure by FTIR spectroscopy and surface morphology by AFM microscopy. The plasma modification changes the sample surface morphology. In vitro cultivation shows that the plasma treatment changes the proliferation of human LEP cells.