In this paper, we consider the analysis of grinding collagen and mathematical function from the cell toxic experiments using interpolation method in new synthetic organic compounds. The extracted collagens and functional cosmetics such as mask, whitening, and serum from collagen are measured with a SEM (Scanning Electron Microscope) and a light-microscope. Also, interpolation method is used for analysis of cell toxic experiments in new synthetic compounds from collagens. The obtained mathematical function can help to provide analytic approach on various toxic substances at different densities. The results can be used as basic data on development for synthesis of new marine functional materials and their derivatives.