Production of Bioactive Nano-Hydroxyapatite/Polysaccharide Composites for Bone Tissue Engineering
Porous κ-carrageenan based composites with potential application in bone tissue engineering have been prepared by in situ co-precipitation of nanoparticles of calcium phosphates, followed by thermally induced gelification and freeze-drying. The scaffolds showed macroporous structure with interconnected porosity. The variation of the biopolymer concentration affected the microstructure and compressive mechanical performance of the composites. The in vitro bioactivity was assessed by soaking the composites in simulated body fluid (SBF) and the formation of an apatite layer on their surface was found.
António Torres Marques, António Fernando Silva, António Paulo Monteiro Baptista, Carlos Sá, Fernando Jorge Lino Alves, Luís Filipe Malheiros and Manuel Vieira
A. L. Daniel-da-Silva et al., "Production of Bioactive Nano-Hydroxyapatite/Polysaccharide Composites for Bone Tissue Engineering", Materials Science Forum, Vols. 587-588, pp. 22-26, 2008