Study on Preparation and Properties of Nitric Oxide Releasing Polyurethane

Abstract:

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In this study, a novel nitric oxide (NO) endogenously releasing polyurethane (PU) material, i.e. PU-g-L-cysteine(PU-Cys), was synthesized by grafting L-cysteine on the film surface. Fluorescence analysis and a BCA method were used to characterize qualitatively and quantitatively the grafted L-cysteine. The results showed that L-cysteine was successfully immobilized on the PU film surface and the density of L-cysteine grafted was calculated to be 15.3nmol/cm2. The NO releasing behavior study of PU-Cys film demonstrated that endogenous NO could be continuously released from PU-Cys film and the accumulated releasing amount within 3h added up to 1.06nmol/cm2. The releasing rate of NO was well matchable to the self-releasing rate of resting platelets in human body. The results of dynamic blood clotting test and hemolysis ratio measurement showed that PU-Cys film had a better haemocompatibility than PU film, which might be the result of endogenously released NO inhibiting platelet adhesion and thrombus formation. Therefore, PU-Cys with the property of endogenous NO releasing is expected to be an ideal blood compatibility material in clinical application.

Info:

Periodical:

Materials Science Forum (Volumes 610-613)

Main Theme:

Edited by:

Zhong Wei Gu, Yafang Han, Fu Sheng Pan, Xitao Wang, Duan Weng and Shaoxiong Zhou

Pages:

1237-1243

DOI:

10.4028/www.scientific.net/MSF.610-613.1237

Citation:

J. H. Zhao et al., "Study on Preparation and Properties of Nitric Oxide Releasing Polyurethane", Materials Science Forum, Vols. 610-613, pp. 1237-1243, 2009

Online since:

January 2009

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Price:

$35.00

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