Crosslinked Electrospun UPM/PHBV/PVP Fibers for Sustained Drug Release
Crosslinked UPM/PHBV/PVP fibers were successfully prepared using electrospinning process. The active pharmaceutical ingredient tetracycline hydrochloride (TH) was loaded onto the electrospun fibers through after-treatment method. Scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) and in vitro dissolution tests were carried out to characterize the medicated electrospun fibers. The SEM and FTIR results clearly showed the difference between the UPM / PHBV and UPM/ PHBV/ PVPelectrospun fibers. The pharmaceutical tests results indicated that the fibers had good drug-loaded capability and sustained-release properties. The as-prepared fibers might find possible applications as wound dressings or transdermal drug delivery systems.
Zhong Wei Gu, Yafang Han, Fu Sheng Pan, Xitao Wang, Duan Weng and Shaoxiong Zhou
J. J. Zhang et al., "Crosslinked Electrospun UPM/PHBV/PVP Fibers for Sustained Drug Release ", Materials Science Forum, Vols. 610-613, pp. 1331-1334, 2009