Crosslinked Electrospun UPM/PHBV/PVP Fibers for Sustained Drug Release

Abstract:

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Crosslinked UPM/PHBV/PVP fibers were successfully prepared using electrospinning process. The active pharmaceutical ingredient tetracycline hydrochloride (TH) was loaded onto the electrospun fibers through after-treatment method. Scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) and in vitro dissolution tests were carried out to characterize the medicated electrospun fibers. The SEM and FTIR results clearly showed the difference between the UPM / PHBV and UPM/ PHBV/ PVPelectrospun fibers. The pharmaceutical tests results indicated that the fibers had good drug-loaded capability and sustained-release properties. The as-prepared fibers might find possible applications as wound dressings or transdermal drug delivery systems.

Info:

Periodical:

Materials Science Forum (Volumes 610-613)

Main Theme:

Edited by:

Zhong Wei Gu, Yafang Han, Fu Sheng Pan, Xitao Wang, Duan Weng and Shaoxiong Zhou

Pages:

1331-1334

DOI:

10.4028/www.scientific.net/MSF.610-613.1331

Citation:

J. J. Zhang et al., "Crosslinked Electrospun UPM/PHBV/PVP Fibers for Sustained Drug Release ", Materials Science Forum, Vols. 610-613, pp. 1331-1334, 2009

Online since:

January 2009

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Price:

$35.00

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