The influence of the titania photocatalyst nano-particles to the skin is to be doubted. We studied the influence of different titania photocatalyst nanoparticles shape to the artificial skin like the human body under the UV light irradiation conditions. The decomposition degree of the artificial skin was evaluated from the monitoring of the amount of carbon dioxide generated from them by the titania photocatalyst nanoparticle activity. When spreading their titania nanoparticles on the skin sample, the carbon dioxide generated from the skin was not detected in the apatite coating titania nano-particle sample through was detected the sample coating no apatite. The result was considered not to have existed the influence on the skin samples because the titania nano-particle was not to touch the skin sample directly.