The green presetting of powders was performed on the substrate by introducing a novel technique namely squash presetting method, and cladding coatings were prepared by crosscurrent CO2 laser in this work. Based on the concept of laser energy efficiency which being accepted generally by insider, the energy efficiency of squash presetting laser cladding was determined. Meanwhile, effects of processing parameters including specific energy, laser power, scanning speed and spot diameter on energy efficiency were investigated through an orthogonal test. The results show that the energy efficiency increases at first and then decreases with the increase of specific energy, and the energy efficiency is relatively higher when laser specific energy ranged from 90 J/mm2 to100 J/mm2. Among three single-factors, the effects of spot diameter on energy efficiency are most significant, laser power takes second place, and scanning speed comes next. It is considered through analysis that the relationship between energy efficiency and processing parameters is closely related to powders melting and heat-conduction course of squash presetting laser cladding.