In Situ Hardening Biodegradable and Malleable Polymer-Nanoapatite Composites
Composite systems composed of nanocrystalline apatites and oligolactide-based polymer networks were prepared resulting in malleable and even injectable formulations which can be cured to compact materials at body temperature. Porous devices with inter-connective porosity were obtained after addition of suitable foaming agents to the composite mixtures. Setting time, porosity and mechanical properties of the composites can be properly adjusted by varying the educt composition. The determined compressive strengths and Young’s moduli of the porous composites perfectly match the mechanical characteristics of cancellous bone material. Preliminary in vitro cell culture experiments with compact composite materials demonstrated their good cytocompatibility. Based on these findings, the synthesized nano-structured composites represent promising candidates for the development of new biomaterials usable in hard tissue regeneration.
T. Chandra, N. Wanderka, W. Reimers , M. Ionescu
S. Berger et al., "In Situ Hardening Biodegradable and Malleable Polymer-Nanoapatite Composites", Materials Science Forum, Vols. 638-642, pp. 693-699, 2010