Molecular Imprinting: Mimicking Molecular Receptors for Antioxidants
Molecularly imprinted polymers (MIPs) have been demonstrated to be a promising class of biomimetic materials that can be tailored to meet specific end use recognition requirements. Molecular imprinting is achieved by the interaction, either covalent or non-covalent between complementary groups in a template molecule and functional monomer units through polymerization. MIPs have been widely employed for divers applications such as chiral separation, chemical sensing, catalysis, drug screening, chromatographic separations and solid phase extraction. During respiration and metabolism, human body produce free radicals as by products, which can damage genetic material, lipids and proteins leading to several fatal diseases such as Cancer, Cardio-vascular disease, Alzheimer’s disease, Immune dysfunction etc. Antioxidants define a family of natural or synthetic nutrients in food, which acts as free radical scavengers. They are present in complex matrix such as herbs, fruit pulp in small concentration, either combined or in free form. Although several techniques have been developed for their detection, (e.g. HPLC, Thin layer chromatography, Capillary gas chromatography, Supercritical fluid chromatography), to achieve highly specific and sensitive analysis, high affinity, stable and specific recognition agents are needed. In this review, special attention is paid to the MIPs based analytical methods for antioxidants, focusing on solid phase extraction, chromatographic and non chromatographic separations and sensing approaches as well as on novel approaches for the discovery of new imprinted materials for antioxidants.
Yi Tan and Dongying Ju
S. Pardeshi et al., "Molecular Imprinting: Mimicking Molecular Receptors for Antioxidants", Materials Science Forum, Vols. 675-677, pp. 515-520, 2011