Combination of Microemulsion for Topical Deliverying Tripterygium Wilfordii Multiglycoside

Abstract:

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The purpose of this study was to explore the potential application of the combination of microemulsion as a topical delivery vehicle in enhancing the absorption and efficacy of tripterygium wilfordii multiglycoside (TWM). Various microemulsion formulations were developed and an optimal microemulsion (TWM-ME),which presented spherical droplets and consisted of RH-40, IPM and water was 27: 3.3: 69.7 by weight. It possessd an average droplet size of 23.6 nm, a low viscosity of (3.56±0.12) mm2•s-1 Zeta electric potential was (–5.35±0.42) mV, refractive index was (1.3617±0.0051) nD20, conductivity was (97.6±3.6) μs/cm. Compared to the control solution, TWM-ME provided better skin permeability in vitro. Moreover, TWM-ME has noticeable anti-inflammatory and immune suppression effect. These results indicate that the combination of microemulsion represents an effective vehicle for topical delivery of TWM.

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Periodical:

Edited by:

Ran Chen

Pages:

881-885

DOI:

10.4028/www.scientific.net/MSF.694.881

Citation:

X. He et al., "Combination of Microemulsion for Topical Deliverying Tripterygium Wilfordii Multiglycoside", Materials Science Forum, Vol. 694, pp. 881-885, 2011

Online since:

July 2011

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$35.00

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