Reconstituted Extracellular Matrix Improve Osteoblastic Differentiation onto Titanium Surfaces

Abstract:

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Electrospinning technique is an efficient processing method to manufacture micro-and nanosized fibrous structures by electrostatic force for different applications. In biomaterial field, electrospinning technique has been successfully utilized to prepare new drug delivery materials and tissue engineering scaffolds. Fiber mats of biodegradable polymers having a diameter in the nanoto submicro-scale can be considered to mimic the nanofibrous structure of native extracellular matrix (ECM). Native extracellular matrix, constituted of proteins and polysaccharides improving cells growth in its nanofibrous porous structure, controls not only the cell phenotype, but the whole structure of the biological tissues. In the present study we investigated the effect of electrospun reconstituted collagen fibers onto metals for oral implants devices manufacturing as far as the osteoblastic differentiation potential of stem cells and cytofunctionality of osteoblasts in-vitro. The cells cultured onto titanium samples coated with ECM constituents showed faster osteoblastic differentiation and more efficient deposition of mineralized matrix in comparison with those onto uncoated substrates.

Info:

Periodical:

Materials Science Forum (Volumes 706-709)

Main Theme:

Edited by:

T. Chandra, M. Ionescu and D. Mantovani

Pages:

584-588

DOI:

10.4028/www.scientific.net/MSF.706-709.584

Citation:

L. Rimondini et al., "Reconstituted Extracellular Matrix Improve Osteoblastic Differentiation onto Titanium Surfaces", Materials Science Forum, Vols. 706-709, pp. 584-588, 2012

Online since:

January 2012

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Price:

$35.00

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