Titanium tetrachloride (TiCl4) oxidation is the most important stage in the titanium dioxide production. High temperature, fast reaction and strong oxidation and strong corrosive atmosphere have increased a lot of difficulty to measuring and testing in oxidation reactor. Computational fluid dynamics (CFD) simulation is one of the most valid methods to investigate TiCl4 gas phase oxidation. In this paper, the achievements and progress about fluid dynamics simulations of titanium tetrachloride gas phase oxidation are described. The further research directions and new perspectives in this field are presented.