Affinity Viscosimetry Sensor for Enzyme Free Detection of Glucose in a Micro-Bioreaction Chamber


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With the growing demand of miniaturization of cell cultivation a new approach towards measuring and sensing bio-analytes needs to be made due to the problem of small volumes (less than 150μl) containing small amounts of analytes. Most of the available glucose sensors monitor the glucose concentration with the help of enzymes, which become very inaccurate in terms of long time measurement and uses (i.e. consumes) glucose during the measurement becoming not available anymore for the cells. Therefore, we focused on applying an enzyme-free glucose sensor based on a microelectromechanical system (MEMS).



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Edited by:

C. Sommitsch, M. Ionescu, B. Mishra, E. Kozeschnik and T. Chandra




T. Liebscher et al., "Affinity Viscosimetry Sensor for Enzyme Free Detection of Glucose in a Micro-Bioreaction Chamber", Materials Science Forum, Vol. 879, pp. 1135-1140, 2017

Online since:

November 2016





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[1] A. Böhme, G. Gatomski, C. Giese, C. -H. Edel und A. -H. Foitzik, A disposable and miniaturized bioreactor system for applications in cell and tissue based experimental in in-vitro environments, Journal of Engineering and Technology, Bd. 1, (2010).

[2] J. Raba und H. A. Mottola, Glucose oxidase as an analytical reagent, Critical reviews in Analytical chemistry, Bd. 25, Nr. 1, pp.1-42, (1995).


[3] K. D. Hardman und C. F. Ainsworth, Structure of concanavalin A at 2. 4-Ang resolution, Biochemistry, Bd. 11, Nr. 26, pp.4910-4919, (1972).


[4] Y. Zhao, S. Li, A. Davidson, B. Yang, Q. Wang und Q. Lin, A MEMS viscometric sensor for continuous glucose monitoring, Journal of micromechanics and microengineering, Bd. 17, Nr. 12, p.2528, (2007).


[5] M. Birkholz, K. -E. Ehwald, T. Basmer, P. Kulse, C. Reich, J. Drews, D. Genschow, U. Haak, S. Marschmeyer, E. Matthus und others, Sensing glucose concentrations at GHz frequencies with a fully embedded Biomicro-electromechanical system (BioMEMS), Journal of Applied Physics, Bd. 113, Nr. 24, pp.244904-244904, (2013).


[6] M. Birkholz, K. -E. Ehwald, D. Wolansky, I. Costina, C. Baristiran-Kaynak, M. Frohlich, H. Beyer, A. Kapp, and F. Lisdat, Surf. Coat. Technol. 204, 2055 (2010).


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