Building Blocks for Artificial Extracellular Matrices Based on Cross-Linkable Polysaccharide and Glycosaminglycan Sulfates
Natural sulfated glycosaminoglycans (GAGs) play a crucial role as components of the extracellular matrix (ECM). They participate in the regulation of important cellular functions including cell growth, differentiation and signalling. The generation of artificial ECM mimicking selected functions of the native ECM is a promising approach to improve the biological acceptance of materials which are in direct contact to living tissue. In this context we developed synthesis routes for polysaccharide and GAG derivatives bearing both bioactive sulfate and reactive (meth) acrylate functions of different degrees of substitution within the sugar repeating unit. In addition, we studied the photochemically initiated cross-linking of these biopolymer derivatives to form biodegradable hydrogels usable as coatings for biomaterials or scaffolds in tissue engineering.
C. Sommitsch, M. Ionescu, B. Mishra, E. Kozeschnik and T. Chandra
J. Becher et al., "Building Blocks for Artificial Extracellular Matrices Based on Cross-Linkable Polysaccharide and Glycosaminglycan Sulfates", Materials Science Forum, Vol. 879, pp. 1270-1275, 2017