Electrospun Polyvinylpyrrolidone (PVP) Nanofiber Mats Loaded by Garcinia mangostana L. Extracts


Article Preview

Composite nanofibers of polyvinylpyrrolidone (PVP) and Garcinia mangostana L. extract (GME) have been synthesized through electrospinning method for application in drug delivery systems. The precursor solution of 10 mL PVP 10% w/w and GME 2% w/w was then electrospun collected at the rotating collector at the following optimum parameters: a voltage of 15 kV, a collector-nozzle distance of 12 cm, and a flow rate of 1 mL/hour. SEM images showed that the average diameters were 476 nm and 690 nm for the PVP and PVP-GME composite nanofibers, respectively. To some degree, the addition of GME into PVP nanofibers increased the average diameter size of nanofibers. Moreover, the release studies, it was shown that 80% of the GME was released within 30 minutes. Therefore, the PVP-GME composite nanofibers can be applied as the drug delivery systems.



Edited by:

Mohd Hamdi Abdul Shukor and Hao Gong




I. Sriyanti et al., "Electrospun Polyvinylpyrrolidone (PVP) Nanofiber Mats Loaded by Garcinia mangostana L. Extracts", Materials Science Forum, Vol. 880, pp. 11-14, 2017

Online since:

November 2016




* - Corresponding Author

[1] M.M. Munir, A.B. Suryamas, F. Iskandar and K. Okuyama: Polymer Vol. 50 (2009), p.4935.

[2] H. Yoshimoto, Y.M. Shin, H. Terai and J.P. Vacanti: Biomaterials Vol. 24 (2003), p. (2077).

[3] O. Suwantong, P. Pankongadisak, S. Deachathai and P. Supaphol: ‎Polym. Bull. Vol. 71 (2014), p.925.

DOI: https://doi.org/10.1007/s00289-014-1102-9

[4] X. Shen, D. Yu, L. Zhu, C. Branford-White, K. White, N.P. Chatterton: Int. J. Pharm Vol. 408 (2011), p.200.

[5] A. Rahma, M.M. Munir, Khairurrijal, A. Prasetyo, V. Suendo and H. Rachmawati: Biol. Pharm. Bull Vol. 39 (2016), p.163.

[6] N.M. Thong, D.T. Quang, N.H.T. Bui, D.Q. Dao, and P.C. Nam: Chem. Phys. Lett. Vol. 625 (2015), p.30.

[7] Y. Akao, Y. Nakagawa, M. Iinuma and Y. Nozawa: Int. J. Mol. Sci. Vol. 9 (2008), p.355.

[8] A.F.A. Aisha, Z. Ismail, K.M. Abu-Salah and A.M.S.A. Majid: J. Pharm. Sci. Vol. 101 (2012), p.815.

[9] X.Y. Dai, W. Nie, Y.C. Wang, Y. Shen, Y. Li and S.J. Gan: J. Mater Sci: Mater. Med. Vol. 23 (2012), p.2709.

[10] S. Ramakrishna, K. Fujihara, W.E. Teo, T. C Lim and Z. Ma: An Introduction to Electrospinning and Nanofibers (World Scientific, Singapore, 2005).

[11] N. Charernsriwilaiwat, T. Rojanarata, T. Ngawhirunpat, M. Sukma and P. Opanasopit: Int. J. Pharm. Vol. 452 (2013), p.333.

[12] M. Ahmad, B.M. Yami and A.M. Lazim: Chem. Cent. J. Vol. 7 (2013), p.85.

[13] C. Risdian, M. Nasir, A. Rahma and H. Rachmawati: J. Nano. Res. Vol. 31 (2015), p.103.