In past few decades, a lot of research has been done in the field of machining to improve the quality of machined surface. Out of these machining operations, drilling is widely used in the areas of marine and aerospace for assembly requirements. Titanium alloy Ti-6Al-4V, owing to its vast applications, is regarded as an important material for these industries. Ti-6Al-4V is categorized as difficult to machine material. Based on above stated facts, an experimental study was conducted on the dry drilling of Ti-6Al-4V. The objective of this study was to establish the correlations between drilling parameters such as feed rate and spindle speed, and quality of machined surface which is evaluated in terms of drill hole diameter deviation, exit burr height and surface roughness.