Solvothermal Synthesis of TiO2-Modified Hydroxyapatite Using Water-Isopropanol Solution


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We synthesized TiO2 nanoparticles dispersed hydroxyapatite (TiO2-modifed HAp) by solvothermal treatment of α-tricalcium phosphate (α-TCP) using water-isopropanol solution including tetraisopropyl orthotitanate (TTIP). Rod-shaped HAp with TiO2 nanoparticles were formed by solvothermal treatment. HAp formation decreased with increasing the isopropanol fraction in the solution with TTIP. With increasing the treatment period, the rate of HAp formation in sample increased. The aspect ratio of HAp decreased with increasing the isopropanol fraction in the solution. Synthesized TiO2-modifed HAp samples shows the photocatalytic decoloration of methylene blue under UV irradiation.



Edited by:

Junichi Hojo, Tohru Sekino, Jian Feng Yang, Hyung Sun Kim and Wen Bin Cao




T. Goto et al., "Solvothermal Synthesis of TiO2-Modified Hydroxyapatite Using Water-Isopropanol Solution", Materials Science Forum, Vol. 922, pp. 86-91, 2018

Online since:

May 2018




* - Corresponding Author

[1] J. Park, Bioceramics: Properties, Characterizations, and Applications, Springer, U.S., (2008).

[2] T. Kawasaki, Hydroxyapatite as a liquid chromatographic packing, J. Chromatogr. A, 544 (1991) 147-184.

[3] M. Galamboš, P. Suchánek, O. Rosskopfová, Sorption of anthropogenic radionuclides on natural and synthetic inorganic sorbents, J. Radioanal. Nucl. Chem., 293 (2012) 613–633.


[4] M. Teraoka, T. Nonami, Y. Yokogawa, H. Taoda, T. Kameyama, Preparation of TiO2-coated hydroxyapatite single crystals, J. Mater. Res., 15 (2000) 1243-1244.


[5] M. Kamitakahara, S. Murakami, N. Watanabe, S. Ji, H. Nishikawa, K. Ioku, Evaluation of photocatalytic activity of anatase/Hydroxyapatite composite granules for environmental purification, J. Ceram. Soc. Japan, 117 (2009) 1172-1174.


[6] H. Anmin, L. Tong, L. Ming, C. Chengkang, L. Huiqin, M. Dali, Preparation of nanocrystals hydroxyapatite/TiO2 compound by hydrothermal treatment, Appl. Catal. B-Environ., 63 (2006) 41-44.


[7] M. Wakamura, K. Hashimoto, T. Watanabe, Photocatalysis by calcium hydrosyapatite modified with Ti(IV): Albumin decomposititon and bactericidal effect, Langmuir 19 (2003) 3428-3431.


[8] T. Goto, T. Sekino, Synthesis of TiO2-modified hydroxyapatite with various morphology by urea-assisted hydrothermal method, Mater. Sci. Forum, 868 (2016) 28-32.


[9] S. Koutsopoulos, Synthesis and characterization of hydroxyapatite crystals: a review study on the analytical methods, J. Biomed. Mater. Res. 62 (2002) 600-612.


[10] Y. Gao, Y. Masuda, W.-S. Seo, H. Ohta, K. Koumoto, TiO2 nanoparticles prepared using an aqueous peroxotitanate solution, Ceram. Int., 30 (2004) 1365-1368.


[11] T. Goto, I.Y. Kim, K. Kikuta, C. Ohtsuki, Hydroxyapatite formation by solvothermal treatment of a-tricalcium phosphate with water-ethanol solution, Ceram. Int., 38 (2012) 1003-1010.


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