Kori Unit 1, which is the oldest nuclear power plant (NPP) in Korea has been operated since 1978. In addition, 10 other NPPs have been operating more than 10 years. As the number of aging plants rise, public concern over the safety of operating NPPs has increased. Periodic safety review (PSR) in addition to the existing safety assessments are proposed by IAEA as an effective way to verify that operating NPPs maintain the high level of safety. In this regard, the Ministry of Science and Technology (MOST), Korea’s nuclear regulatory body, recently established an institutional process through revision to the atomic energy act to introduce PSR. This PSR considers, among other factors, improvements in safety standards and practices, the cumulative effects of plant aging, operating experience, and the evolution of science and technology. In particular, the assessment and management of plant aging is one of the major areas. It includes identification of the system, structure and components (SSCs) for aging management, assessment of aging effects and planning of aging management implementation program. PSR results could be one of the procedural requirements that are utilized to renew an operating license of a NPP. This paper describes safety assessment requirements including PSR and aging management activities in Korea. This paper also includes the strategy and method for the application of PSR results to the aging management and continued operation of NPPs.