Large scale wedge/aspheric lens element is a combination of wedge prism and aspheric lens as a single piece component forming a decentred lens, which is primarily manufactured by Computerized Numerical Control (CNC) machining, especially 3-axis CNC grinding. This paper presents an efficient tool path generation approach based on isophote interpolation. The interpolation guarantees that interpolated points always stay on the iso-inclination curve of the parametric surface. This symmetry ensures that the method can improve and automate large scale wedge/aspheric lens element machining for 3-axis CAD/CAM systems. As part of the validation process, the tool paths generated are analyzed and compare with the desired part.