Biodegradation of Nanoparticles in a Body from Mössbauer and Magnetization Measurements
In order to extract a quantitative information about characteristics of the magnetic nanoparticles injected into a living organism one has to define a model of the magnetic dynamics in order to fit self-consistently the whole set of the experimental data, particularly, the evolution of Mössbauer spectral shape with temperature and external magnetic field as well as the magnetization curves. We have developed such a model and performed such an analysis of the temperature-and magnetic field-dependent spectra and magnetization curves of nanoparticles injected into a mice. This allowed us to reliably evaluate changes in the residual nanoparticles characteristics and their chemical transformation to paramagnetic ferritin-like forms in different mouses organs as a function of time after injection of nanoparticles. Actually, the approach allows one to quantitatively characterize biodegradation and biotransformation of magnetic nanoparticles injected into a body.
N. Perov and V. Rodionova
M. Chuev et al., "Biodegradation of Nanoparticles in a Body from Mössbauer and Magnetization Measurements", Solid State Phenomena, Vol. 190, pp. 725-728, 2012