Biodegradation of Nanoparticles in a Body from Mössbauer and Magnetization Measurements


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In order to extract a quantitative information about characteristics of the magnetic nanoparticles injected into a living organism one has to define a model of the magnetic dynamics in order to fit self-consistently the whole set of the experimental data, particularly, the evolution of Mössbauer spectral shape with temperature and external magnetic field as well as the magnetization curves. We have developed such a model and performed such an analysis of the temperature-and magnetic field-dependent spectra and magnetization curves of nanoparticles injected into a mice. This allowed us to reliably evaluate changes in the residual nanoparticles characteristics and their chemical transformation to paramagnetic ferritin-like forms in different mouses organs as a function of time after injection of nanoparticles. Actually, the approach allows one to quantitatively characterize biodegradation and biotransformation of magnetic nanoparticles injected into a body.



Solid State Phenomena (Volume 190)

Edited by:

N. Perov and V. Rodionova




M. Chuev et al., "Biodegradation of Nanoparticles in a Body from Mössbauer and Magnetization Measurements", Solid State Phenomena, Vol. 190, pp. 725-728, 2012

Online since:

June 2012




[1] M.A. Chuev and J. Hesse, Non-Equilibrium magnetism of single-domain particles for characterization of magnetic nanomaterials, in: K. B. Tamayo (Ed. ), Magnetic Properties of Solids, Nova Science Publishers, New York, 2009, pp.1-104.

[2] G.C. Papaefthymiou, The Mössbauer and magnetic properties of ferritin cores, Biochimica et Biophysica Acta 1800 (2010) 886-897.


[3] M.A. Chuev, V.M. Cherepanov, S.M. Deyev, I.N. Mischenko, M.P. Nikitin, M.A. Polikarpov and V.Y. Panchenko, Interpretation of the Mössbauer spectra of the magnetic nanoparticles in mouse spleen, AIP Conf. Proc. 1311 (2010) 322-328.


[4] D.H. Jones and K.K.P. Srivastava, Many-state relaxation model for the Mössbauer spectra of superparamagnets, Phys. Rev. B34 (1986).

[5] J. van Lierop and D.H. Ryan, Mössbauer spectra of single-domain fine particles systems described using a multi-level relaxation model for superparamagnets, Phys. Rev. B63 (2001).


[6] M.A. Chuev, M.A. Polikarpov, V.M. Cherepanov, Magnetic-nanoparticle diagnostics based on analysis of hyperfine structure of Mössbauer spectra in a weak magnetic field, Doklady Phys. 55 (2010).


[7] M.A. Chuev, Mössbauer spectra of single-domain particles in a weak magnetic field, J. Phys.: Condens. Matter 20 (2008).