Papers by Author: Betty León

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Authors: Lourdes Rial, P. Rodal, Miriam López-Álvarez, Jacinto P. Borrajo, Eugenio Luís Solla, Julia Serra, Pio González, Betty León
Abstract: In this research, bioactive glass powders were electrophoretically deposited on biomorphic SiC ceramic substrates. A post-deposition thermal treatment was carried out to improve the properties of the coatings. Particle size, surface morphology, composition and thickness of the coatings have been studied by Scanning Electron Microscopy (SEM), Energy Dispersive Spectroscopy (EDS) and interferometric profilometry respectively. The analysis demonstrated that the electrophoresis parameters, such as the voltage, the distance between the electrodes and the deposition time, play an important role on the thickness of the coatings. The post-deposition thermal treatment produces glass particles cohesion and leads to obtaining a homogeneous microstructure. The excellent coverage of the porous SiC surface morphology is also demonstrated. Finally, in order to assess the bioactive character of the glass coatings, in vitro test by immersion in simulated body fluid (SBF) was carried out.
Authors: Jacinto P. Borrajo, Pio González, Julia Serra, Sara Liste, Stefano Chiussi, Betty León, Alejandro de Carlos, Francisco M. Varela-Feria, Julian Martínez-Fernández, António Ramirez de Arellano-López
Abstract: There is a need to develop new tough bioactive materials capable to withstand high loads when implanted in the body and with improved fixation, which led to the production of bioactive coatings on metallic substrates. A new approach, which consists of biomorphic silicon carbide (SiC) coated with bioactive glass, was recently presented. This new material joins the high mechanical strength, lightness and porosity of biomorphic SiC, and the bioactive properties of PLD glass films. In this work, a multiple evaluation in terms of biocompatibility of this new material was carried out starting from the biomorphic SiC morphology and porosity, following with the bioactivity of the coatings in simulated body fluid, and ending with a deep biocompatibility study with MG-63 cells. Different ranges of porosity and pore size were offered by the biomorphic SiC depending on the starting wood. The PLD glassy coatings had a high bioactivity in vitro and both the biomorphic SiC coated and uncoated presented high levels of biocompatibility.
Authors: M.P. Ferraz, F.J. Monteiro, D. Gião, Betty León, Pio González, Sara Liste, Julia Serra, J.L. Arias, Mariano Pérez Amor
Authors: Frank Malz, H. Aguiar, Eugenio Luís Solla, Julia Serra, Pio González, Betty León, Christian Jaeger
Abstract: The results of a combined structural characterisation (XRD, IR, NMR, SEM, TEM) of a phosphate containing Mg-Ca silicate and a phosphate containing Na-Ca silicate glass samples are presented. The structural results are also compared with in vitro tests carried out in simulated body fluids for checking bioactivity.
Authors: Jacinto P. Borrajo, Sara Liste, Julia Serra, Pio González, Stefano Chiussi, Betty León, Mariano Pérez Amor
Abstract: The structure of silica-based glasses consists on a disrupted network of SiO4 tetrahedra where network modifiers generate non-bridging oxygen groups (NBO), that play an important role at the initial steps of the bioactive process. Infrared spectroscopy is a sensitive technique to the presence of NBO groups and glass local structure modifications. The infrared study has been complemented with a theoretical approach using the Y Stevels parameter. Moreover, the in vitro bioactivity of the glasses as a function of Y Stevels paremeter has been studied, which can be a finding of a predictive tool for bioactivity of glasses.
Authors: Pio González, Jacinto P. Borrajo, Julia Serra, Sara Liste, Stefano Chiussi, Betty León, K. Semmelmann, Alejandro de Carlos, Francisco M. Varela-Feria, Julian Martínez-Fernández, António Ramirez de Arellano-López
Authors: Sara Liste, Pio González, Julia Serra, C. Serra, Jacinto P. Borrajo, Stefano Chiussi, Betty León, Mariano Pérez Amor
Authors: Alejandro de Carlos, Jacinto P. Borrajo, Julia Serra, Pio González, Sara Liste, Betty León
Abstract: The aim of this study was to test the in vitro cytotoxicity of wood-based biomorphic Silicon Carbide (SiC) ceramics, using MG-63 human osteoblast-like cells. This innovative material has been recently developed and it exhibits unique mechanical properties towards their application in biomedical technology. In the solvent extraction test the SiC ceramic extracts had almost no effect on cellular activity even at 100% concentration. A similar behaviour was found for Ti6Al4V and bioactive glass, used as reference materials. The results of the cell morphology and the cellular attachment response have also demonstrated that the in vitro performance of these biomorphic SiC ceramics is qualitatively comparable to that produced by titanium alloy and bioactive glass, which seems very promising.
Authors: M.D. Paz, Stefano Chiussi, L. González, Julia Serra, Betty León, L. Goikoetxea, J.I. Alava
Authors: Eugenio Luís Solla, Jacinto P. Borrajo, Pio González, Julia Serra, Stefano Chiussi, Betty León, Mariano Pérez Amor
Abstract: The bioactive properties of hydroxyapatite (HA) are well known in the implant industry and coatings of HA have been used to enhance the adhesion of living tissue to metal prostheses. Pulsed laser deposition (PLD) in a water vapour atmosphere is an appropriate method for the production of crystalline HA coatings. In this work the effect of RF plasma on thin films of HA grown by PLD at different substrate temperatures has been studied. The physicochemical properties of the films were studied by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and energy dispersive spectroscopy (EDS), showing that the incorporation of RF discharge in the deposition chamber can lead to changes in the crystallinity and deposition rate of the films but substrate temperature still plays the most important role.
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