Papers by Author: Bing Chun Zhang

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Authors: Yi Bin Ren, Hua Juan Yang, Ke Yang, Bing Chun Zhang
Abstract: The in vitro blood compatibility of a new nickel free high nitrogen austenitic stainless steel Fe-Cr-Mn-Mo-N (BIOSSN4) was studied by the kinetic clotting time test and the platelet rich plasma adhesion test in this paper. In comparison with 316L stainless steel, the kinetic clotting time of BIOSSN4 steel are longer, and only causes less activation of platelets in platelet adhesion test, which was indicated by their morphology and low spreading. The experimental results reveals that the BIOSSN4 stainless steel has better blood compatibility, the blood compatibility mechanism of steels was analyzed based on surface tension and interfacial tension between the steels and blood.
Authors: Yi Bin Ren, Hao Wang, Jing Jing Huang, Bing Chun Zhang, Ke Yang
Abstract: Magnesium and its alloys are possible to develop new type of biodegradable medical magnesium alloys by using their active corrosion potential. The bio-corrosion properties of the high pure magnesium in the Hank’s solution were investigated in this paper, the results showed that high pure magnesium had a low corrosion rate and hydrogen release in Hank’s solution, when the pH value of solution was controlled at 7.5, the corrosion rate was under 0.2mm/year, the production of hydrogen was about 0.15ml/cm2, and if the solution wasn’t controlled on pH value, the corrosion rate was about 0.02 mm/year, production of hydrogen was about 0.1ml/cm2 . Result of in vitro Kinetic clotting time test and animal implant prep-test showed that High pure magnesium had good thromboresistant property and tissue compatibility, pure magnesium can biodegrade lowly in animal body and formed surface apatite, which proportion of Ca/P was similar with bone tissue.
Authors: Li-Li Tan, Ke Yang, Bing Chun Zhang, Yong Liang
Abstract: Implantation of drug releasing coronary stents has been developed as an useful method for prevention of the restenosis in blood vessels. Copolymers of methyl methacrylate (MMA), butyl methacrylate (BMA) and methacrylic acid (MAA) were prepared as the coating polymer for drug releasing stent. The adhesion of the polymer with metal substrate and the biocompatibility were studied. Effect of the polymer composition on the adhesion between polymer coatings and metal substrate, as well as the effect of the polymer purification method on biocompatibility of the polymer, was studied. The results showed that the copolymer coating has good dry and wet adhesion properties, which can be improved by control of the polymer compositions. Biocompatibility of the prepared copolymer comes within the permission limit.
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