Papers by Author: C. Rolfe Howlett

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Authors: Chao Yuan Wang, You Rong Duan, Xin Long Wang, Boban Markovic, James Barbara, C. Rolfe Howlett, Hala Zreiqat, Xing Dong Zhang
Abstract: Hydroxyapatite (HA) ceramics is one of the most widely used bone substitute in clinics. Limited information is available concerning how HA ceramics may affect osteoprotegerin (OPG) and RANKL expression. In this study, osteoblastic-like SaOS-2 cells were grown on HA ceramics sintered at different temperature for 3 and 6 days, RANKL and OPG mRNA expression were analyzed with quantitative in situ hybridization (QISH) technique. Result showed that SaOS-2 grown on HA ceramics sintered at 800°C expressed higher RANKL mRNA than on other two HA ceramics after 3 days’ culture. No significant difference in OPG expression on different surfaces was detected after 3 days and 6 days culture. This result suggests that HA sintered at low temperature tend to induce more bone remodeling after implantation.
Authors: Hala Zreiqat, C. Rolfe Howlett, A. Zannettino, P. Evans, Christine Knabe, G. Schulze-Tanzil, G.M. Shakibaei
Authors: Peter A. Revell, Elsie Damien, X.S. Zhang, P. Evans, C. Rolfe Howlett
Authors: Christine Knabe, C. Rolfe Howlett, Boban Markovic, Georg Berger, Renate Gildenhaar, Hala Zreiqat
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