Papers by Author: Gilbert Fantozzi

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Authors: Gilbert Fantozzi
Authors: Gilbert Fantozzi
Authors: Gilbert Fantozzi
Authors: R. Schaller, Gilbert Fantozzi
Authors: Ovidiu Dumitrescu, Yves Jorand, Gilbert Fantozzi
Authors: Hassan El Attaoui, Malika Saâdaoui, Jérôme Chevalier, Gilbert Fantozzi
Authors: E.M. Bourim, B.L. Cheng, M. Gabbay, Gilbert Fantozzi
Authors: Aurélien Bignon, F. Laurent, J. Goldnadel, Jérôme Chevalier, Gilbert Fantozzi, E. Viguier, T. Roger, Georges Boivin, D.J. Hartmann
Abstract: Despite systemic prophylaxis, infection rates after orthopedic surgery can reach more than 1%. A new HAP/TCP bone substitute loaded with 125 mg of gentamicin was designed for prophylactic use. Its aim was to enhance the efficacy of systemic prophylactic treatments by increasing the local antibiotic concentration. For prophylactic applications, release had to take place within 48 hours not to select antibiotic-resistant bacterial strains. The purpose of this study was to investigate the releasing mechanisms of gentamicin from the porous HAP/TCP matrix. The release rate of gentamicin trough the porosities of the bone substitute was investigated in vitro, in 0.9% sodium chloride solution. The rate appeared to be related to the bone substitute volume and fit classical diffusion laws. All the gentamicin was released in less than 48 hours: this rate corresponds to the recommendations for the prophylactic use of antibiotics.
Authors: Paola Palmero, Claude Esnouf, Laura Montanaro, Gilbert Fantozzi
Abstract: Two α-Al2O3/YAG composite powders have been prepared by reverse-strike precipitation, starting from chlorides aqueous solutions, the former containing 50 vol% of the two phases (labelled as AY50) and the latter made of 90 vol% of alumina and 10 vol% of YAG (AY90). The as-prepared powders were characterised by DTA/TG simultaneous analysis as well as by XRD analysis performed after calcination at different temperatures. A systematic TEM analysis was performed on AY50 powders pre-treated at different temperatures, in order to investigate the crystallites size evolution as a function of the temperature. After that, samples were compacted by uniaxial pressing and sintered at 1600°C for 3h. SEM observations revealed a homogeneous microstructure made of micronic alpha-alumina and YAG grains. For limiting grain growth through the decreasing of the maximum sintering temperature, an innovative activation procedure by coupling suitable thermal and mechanical treatments of the powders was performed. After that, high densification (>95% of the theoretical density) was easily achieved by performing a free sintering in the temperature range between 1320° and 1420°C, with different soaking times at the maximum temperature. The resulting sintered bodies showed an effective retention of the nano-size of the primary particles. By SEM, highly-homogeneous nanostructures, with an average grains size of about 200 and 300 nm for AY50 and AY90, respectively, were observed.
Authors: Antonio H. De Aza, Jérôme Chevalier, Gilbert Fantozzi, Martin Schehl, Ramon Torrecillas
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