Papers by Author: Jian Liu

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Authors: Sheng Min Zhang, W. Zhou, Jian Liu, L. Cheng, P.P. Chen
Abstract: A novel synthesis of nano-fluoride-substituted hydroxyapatite (nano-F-HAP) was successfully realized through dialysis process within 4 h, which required much shorter time than the methods reported so far. In new preparation, a dialysis was employed to purify unwanted ions. The removal efficiency of impurity ions in dialysis was evaluated by calculating the concentration of the representative irons NH4 + between the inner slurry and outer distilled water. Results showed that total dialysis efficiency came to 94.5%. The final products were characterized by XRD, HR-TEM, and FT-IR. The XRD and FT-IR results strongly supported substitution of F- for OH-, and the TEM pictures further indicated that the final crystals are about 100nm in length and about 20 nm in diameter without obvious aggregation. Therefore, comparing with traditional purifying processing, such a new synthesis provides a promising application for scale preparation of fine nano-F-HAP crystals.
Authors: P.P. Chen, Sheng Min Zhang, L. Cheng, S.L. Huang, Jian Liu, W. Zhou, H. Gong, Q.M. Luo
Abstract: In this paper, three different scale HA/PDLLA porous scaffolds, nano-HA/PDLLA, micro-HA/PDLLA and pure PDLLA were successfully fabricated using solvent casting/particulate leaching method. Chondrocytes adhesion and proliferation on these scaffolds were investigated. In detail, the cells attachment rate and proliferation on nano-HA/PDLLA, micro-HA/PDLLA and pure PDLLA were quantitatively evaluated by cytometry. The interaction between the scaffolds and chondrocytes were observed by optical microscope with HE staining and FE-SEM. The results exhibited that nano-HA/PDLLA scaffold has a modified cell adhesion property, and cells on the nano-scaffold grow much better both in biological and morphological characteristics than on the micro-HA/PDLLA and pure PDLLA scaffolds. This work suggested that nano-HA/PDLLA composite scaffold can significantly improved cell adhesion and proliferation tendency with the existing of nano-effects,and could be used as a potential scaffold material for bone defect repair.
Authors: Sheng Min Zhang, Rui Rui Cao, Jian Liu, L. Liu, P. Lu, W. Zhou, L. Cheng, P.P. Chen, Q.M. Luo
Abstract: Crucumin (diferuloylmethane) is a major active component of turmeric, but its bioavailability of oral administration is very low. In order to improve its pharmaceutical efficiency in oral use, poly (d,l-lactide) (PDLLA) nanospheres containing curcumin are successfully fabricated using a modified spontaneous emulsification solvent diffusion (SESD) method. The morphology, size and distribution of the resulting nanospheres are characterized by TEM and laser light scattering method. Drug contents in the nanospheres are calculated through UV spectrophotometer method. As a result, regular spherical PDLLA nanospheres containing curcumin are obtained and their effective diameters are 289 nm with narrow distribution (Pd=0.118)
Authors: L. Cheng, Sheng Min Zhang, P.P. Chen, S.L. Huang, Rui Rui Cao, W. Zhou, Jian Liu, Q.M. Luo, H. Gong
Authors: Yu Xue Chen, Jian Liu
Abstract: A system for on-line measurement and sorting of ball bearings is presented in this paper. The structures and functions of its automatic testing mechanics and control system are described in detail. The system sorts the tested bearings into four grades by measured values of vibration parameters such as root-mean-square value, peak value, crest factor and kurtosis. Its stability of indication values is between ± 1.0 dB. The mechanism generating abnormal sounds of bearings is also investigated emphatically and the characteristics of abnormal sound signals are described on the basis of vibration model of tested bearing.
Authors: H. Lu, S.M. Zhang, L. Cheng, P.P. Chen, W. Zhou, Jian Liu, J.X. Zhou
Abstract: A novel porous composite scaffold of nano-HA/poly (lactic-co-glycolic) (PLGA) was fabricated by solvent casting/particulate leaching method. Chondrocytes were isolated from the knee articular joints of a rabbit, and then seeded in the scaffolds. The cell-loaded scaffolds were cultured in vitro for 5 days before implantation. Full-thickness articular cartilage defects were created in rabbits, and filled with and without the cell-loaded nano-HA/PLGA scaffolds. The implants were harvested after in vivo incubation of 2 and 5 weeks. Cartilaginous tissues were observed at defects repaired with the cell-loaded scaffolds, while only fibrous tissues were found for the control groups. The repaired tissues were evaluated histologically by hematoxylin and eosin staining. Results revealed that nano-HA/PLGA composite scaffolds facilitated adheration of cells in vitro, and the nano-HA particles could prevented the scaffolds from collapsing and promoted the formation of cartilaginous tissue in vivo.
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