Papers by Author: Luigi de Nardo

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Authors: G. Rondelli, M. Francesca Brunella, Luigi de Nardo, Alberto Cigada
Authors: Silvia Farè, Luigi de Nardo, S. De Cicco, M. Jovenitti, Maria Cristina Tanzi
Abstract: In the last few years, clinical procedures undergone huge modifications. Among them, mini-invasive surgery has modified the clinical practice and the quality of life of patients. Shape Memory Polymers (SMPs), a class of stimuli-responsive materials, can be considered ideal candidates for the design of devices for mini-invasive surgical procedures. Such a device can be inserted in a packed in, temporary shape and later can expand at body temperature. A bone defect could be filled by a SMP porous structure, that improves the tissue integration and healing. In this work, two different processing techniques to obtain porous shape memory polymer scaffolds from Calo MER™ and MM-4520, two SMPs, are presented. Porous structures were obtained by micro-extrusion with different chemical foaming agents or with sodium chloride, or by solvent casting/particulate leaching. The morphology, the thermo-mechanical and the shape recovery properties of the SMP porous samples were investigated. Tridimensional porous structures showed a well interconnected morphology, with a pore size in the range aimed for bone interaction applications. The shape memory properties were not significantly affected by the transformation processes: a good ability of recovering the original shape was verified. Therefore, the porous structures, obtained from these SMP materials, appear adequate for an use as bone filler.
Authors: Linda Vecbiskena, Luigi de Nardo, Roberto Chiesa
Abstract: This work is focused on the phase transformation from amorphous calcium phosphate (ACP) to nanostructured hydroxyapatite (HA) or tricalcium phosphate (TCP). Amorphous calcium phosphates with Ca/P molar ratio near 1.67 and 1.5 were synthesized by wet-chemical precipitation method and treated with ethanol. Upon thermal treatment, ACP clusters about 50 nm create a nanostructured HA or TCP. The highlights of this research: The precipitate treatment with ethanol provided a pure α-TCP that was found to be stable up to 1000 °C. HA is obtained from the ACP precursor synthesized using also ammonium dihydrogen phosphate.
Authors: Lina Altomare, Serena Bertoldi, Monia Montorsi, Gabriele Candiani, Alberto Cigada, Luigi de Nardo
Abstract: Cathodic polarization is a powerful technique largely used for the deposition of thin films on metallic substrates; it offers the distinctive advantage of an easy control over the composition, thickness, and morphology of the films by simply adjusting the process parameters such as the electrolyte bath composition, the applied potential (or current density), and the process duration. In this work, electrochemical deposition (ECD) was exploited to engender biopolymer blends composed by chitosan/collagen and chitosan/poly (ethylene oxide) and deposited at different weight ratios (5:1, 3:1) and compared to pristine material. Our findings demonstrate that ECD is an effective technique for the preparation of scaffolds made of chitosan blends in which morphology and mechanical properties can be optimized via scaffold composition.
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