Papers by Author: Masami Hirohashi

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Authors: Yasuo Morimoto, Masami Hirohashi, Masanori Horie, Akira Ogami, Takako Oyabu, Toshihiko Myojo, Masayoshi Hashiba, Yohei Mizuguchi, Tatsunori Kambara, Byeong Woo Lee, Etsushi Kuroda, Kazuhiro Yamamoto, Norihiro Kobayashi, Shigehisa Endoh, Kunio Uchida, Tetsuya Nakazato, Katsuhide Fujita, Junko Nakanishi, Isamu Tanaka
Abstract: Single-Wall Carbon Nanotubes (SWCNTs) Were Well-Dispersed Using Ultrasonication to Conduct an Intratracheal Instillation Study. The Geometric Mean Diameter and Length of the SWCNT in Distilled Water Including 0.1 % Triton X-100 Was 44 Nm and 0.69 μm, Respectively. Rats Intratracheally Received 0.2 Mg or 0.4 Mg of SWCNT, and a Control Group Received Intratracheal Instillation of Distilled Water Containing 0.1 % Triton X-100 . The Rats Were then Sacrificed at 3 Days, 1 Week, 1 Month, 3 Months and 6 Months after Instillation. Bronchoalveolar Lavage Fluid (BALF) and Pathological Features Revealed that the Dose of SWCNT Induced Persistent Neutrophil Infiltration in Rat Lungs. In the Cytokine-Induced Neutrophil Chemoattractants (CINCs) Family, the Concentrations of CINC-1 and CINC-2 in the BALF Increased Persistently in the SWCNT-Exposed Groups. the Concentration of HO-1 in the BALF Was Also up-Regulated Persistently in the Exposed Groups. These Data Suggested that Well-Dispersed SWCNT Had an Inflammatory Potential in the Present Study.
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