Papers by Author: Stefano Chiussi

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Authors: Jacinto P. Borrajo, Pio González, Julia Serra, Sara Liste, Stefano Chiussi, Betty León, Alejandro de Carlos, Francisco M. Varela-Feria, Julian Martínez-Fernández, António Ramirez de Arellano-López
Abstract: There is a need to develop new tough bioactive materials capable to withstand high loads when implanted in the body and with improved fixation, which led to the production of bioactive coatings on metallic substrates. A new approach, which consists of biomorphic silicon carbide (SiC) coated with bioactive glass, was recently presented. This new material joins the high mechanical strength, lightness and porosity of biomorphic SiC, and the bioactive properties of PLD glass films. In this work, a multiple evaluation in terms of biocompatibility of this new material was carried out starting from the biomorphic SiC morphology and porosity, following with the bioactivity of the coatings in simulated body fluid, and ending with a deep biocompatibility study with MG-63 cells. Different ranges of porosity and pore size were offered by the biomorphic SiC depending on the starting wood. The PLD glassy coatings had a high bioactivity in vitro and both the biomorphic SiC coated and uncoated presented high levels of biocompatibility.
970
Authors: Jacinto P. Borrajo, Sara Liste, Julia Serra, Pio González, Stefano Chiussi, Betty León, Mariano Pérez Amor
Abstract: The structure of silica-based glasses consists on a disrupted network of SiO4 tetrahedra where network modifiers generate non-bridging oxygen groups (NBO), that play an important role at the initial steps of the bioactive process. Infrared spectroscopy is a sensitive technique to the presence of NBO groups and glass local structure modifications. The infrared study has been complemented with a theoretical approach using the Y Stevels parameter. Moreover, the in vitro bioactivity of the glasses as a function of Y Stevels paremeter has been studied, which can be a finding of a predictive tool for bioactivity of glasses.
465
Authors: Pio González, Jacinto P. Borrajo, Julia Serra, Sara Liste, Stefano Chiussi, Betty León, K. Semmelmann, Alejandro de Carlos, Francisco M. Varela-Feria, Julian Martínez-Fernández, António Ramirez de Arellano-López
1029
Authors: Sara Liste, Pio González, Julia Serra, C. Serra, Jacinto P. Borrajo, Stefano Chiussi, Betty León, Mariano Pérez Amor
355
Authors: M.D. Paz, Stefano Chiussi, L. González, Julia Serra, Betty León, L. Goikoetxea, J.I. Alava
625
Authors: Eugenio Luís Solla, Jacinto P. Borrajo, Pio González, Julia Serra, Stefano Chiussi, Betty León, Mariano Pérez Amor
Abstract: The bioactive properties of hydroxyapatite (HA) are well known in the implant industry and coatings of HA have been used to enhance the adhesion of living tissue to metal prostheses. Pulsed laser deposition (PLD) in a water vapour atmosphere is an appropriate method for the production of crystalline HA coatings. In this work the effect of RF plasma on thin films of HA grown by PLD at different substrate temperatures has been studied. The physicochemical properties of the films were studied by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and energy dispersive spectroscopy (EDS), showing that the incorporation of RF discharge in the deposition chamber can lead to changes in the crystallinity and deposition rate of the films but substrate temperature still plays the most important role.
1029
Authors: Jacinto P. Borrajo, Sara Liste, Julia Serra, Pio González, Stefano Chiussi, Betty León, Mariano Pérez Amor, Heimo O. Ylänen, Mikko Hupa
23
Authors: M.D. Paz, Stefano Chiussi, Pio González, Julia Serra, Betty León, J.I. Alava, I. Güemes, F.M. Sanchez-Margallo
Abstract: In the present work two different hydroxyapatite nanofilms (50 and 100 nm thick) have been successfully deposited on titanium implants that were previously laser macrostructured in order to assess the influence of the thickness of nanometric calcium phosphate coatings on the osseointegration. Cylindrical implants were tested in a sheep tibia model together with titanium alloy controls achieving very good osseointegration results. Laser macrostructured titanium alloy implants have shown improved bone regeneration when coated with nanometric films of carbonated HA. The pulsed laser deposited nanofilm has promoted bone in-growth deep into the laser ablated craters. There were no significant differences between the two coating thicknesses, neither when assessed with electron microscopy or classical optical methods. This result suggests that the 50 nm coating is as effective as the 100 nm one, therefore implying that the thickness limit for such a bioactive layer to stimulate bone growth may be even further below.
645
Authors: Julia Serra, Pio González, Stefano Chiussi, Betty León, Mariano Pérez Amor
635
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