Papers by Author: Xu Yan Tang

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Authors: Quan Li Li, Nan Huang, Zhi Qing Chen, Xu Yan Tang
Abstract: Phosphorylated chitosan (PCS) was used as the template to control hydroxyapatite(HAp) growth, a novel nanocomposite composed of PCS and HAp was synthesized by biomimetic method. Calcium phosphate (Ca 2+= 60mM, Ca/P = 1.67) solution in HCl was added dropwise into PCS solution in NaOH. The precipitate was lyophilized to obtain the composite. The biocompatibility of the PCS-HAp nanocomopite was evaluated by osteoblast culture in vitro. The results showed that low crystallized HAp nanocrystals was formed on the PCS fibers and its crystallographic c-axis were aligned preferentially parallel to the long axis direction of PCS; the composite have good biocompatibility in vitro. It is expected that the novel composite to be a potential material for bone repair.
Authors: Jing Jing Luo, Tian Yun Ning, Ying Cao, Xiao Peng Zhu, Xiao Hua Xu, Xu Yan Tang, Chun Hung Chu, Quan Li Li
Abstract: We here report a novel biomimetic mineralization strategy for enamel remineralization by intergration of calcium phosphate loaded and thermally triggered liposomes and a self-assembly amelogenin-inspired peptide. Firstly, calcium and phosphate loaded temperature sensitive liposomes were synthesized by Interdigitation-fusion method with 1,2-bis(palmitoyl)-sn-glycero-3-phosphor- choline (DPPC) and 1,2-bis(myristoyl)-sn-glycero- 3-phosphocholine (DMPC) at mass ratio of 9:1 . The liposomes were stable at room temperature, but slowly released calcium and phosphate ions if heated to 37 °C. Secondly, a novel polyanion amelogenin-inspired oligropeptide (Gln-Pro-Ala)4-Thr-Lys-Arg-Glu-Glu-Val-Asp ) was synthesized by standard solid-phase. Lastly, the mixture of peptide and liposomes solution was exposed to enamel surface at 37 °C. The results showed oriented enamel-like hydroxylapatite evenly deposited on enamel surface.
Authors: Quan Li Li, Nan Huang, Guo Jiang Wan, L.S. Zhao, Xu Yan Tang
Abstract: The ultra-thin film composed of chitosan (CS) and sulfated chitosan (SCS) was assembled on the titanium oxide surface by layer-by-layer (LBL) self-assembly methods. The titanium oxide film was treated by NaOH solution, followed by successively dipping the substrates in 5mg/ml sulfated chitosan (SCS) and 5mg/ml chitosan (CS) solutions alternatively, We hypothesized that this biologic coating may have the property of good biocompatibility, antibacteriostatic effect, anticoagulant activitves and enhancing sell biocompatibility.
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