Papers by Author: Yun Mao Liao

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Authors: Xin Chang Shi, H.Z. Jiang, J. Xue, Yun Mao Liao, L.Y. Xiao, C.Y. Bao, W. Li
Abstract: In order to modify the biological properties of pure hydroxyapatite (HAp), two kinds of zinc-containing HAp, which had zinc content of 5.10wt% and 2.54wt%, respectively, were synthesized via sol-gel technique. The obtained coatings were characterized by X-ray diffraction (XRD) and scanning electron microscope (SEM). Then the antibacterial effects were evaluated through bacteriostatic test on Streptococcus mutans (S.mutans) in vitro and zinc ions releasing ability was investigated through detecting the zinc ions concentration by inductively coupled plasma-atomic emission spectroscopy (ICP-AES). The obtained coatings were observed to possess typical apatite peaks in XRD patterns and high homogeneous and porous surfaces in SEM morphology. The coating layer demonstrated good releasing ability in Brain Heart Infusion (BHI) liquid and obviously inhibitory effects to the growth and proliferation of S. mutans. Based on the results obtained above, it is concluded that the sol-gel derived zinc-containing hydroxyapatite could be applied as an antibacterial effective biomaterial.
Authors: Lan Lei Wang, He Ying Hou, Jian Xin Zhang, Zong Mei Sun, Pi Shan Yang, Yun Mao Liao
Abstract: The aim of the present study was to assess the effect of nano-biphasic calcium phosphate (nanoBCP) scaffolds on acute alveolar bone defects in beagle dogs by micro-computed tomographic imaging (μCT). Alveolar bone defects were surgically created bilaterally at the buccal aspects of the upper second premolars in four beagle dogs. After root conditioning with ethylenediaminetetraacetate (EDTA), nanoBCP was randomly filled in the defects and nothing was put into the contralateral defects as controls. Dogs were killed at the 24th weeks. Specimens were scanned and reconstructed though μCT. The results revealed that much new alveolar bone formed in the defects in the nanoBCP groups while no new alveolar bone formed in the controls. The present results indicate that PBCP may enhance alveolar bone regeneration in acute-type labial dehiscence defects.
Authors: Xia Deng, Gang He, Yun Mao Liao, Yong Yi Yao, Zhi Qing Chen, Gang Li, Yong Zhao, Rong Rong Nie, Zhi Hong Liang, Yi Li Qu, Kun Tian
Abstract: A three-dimensional biomimetic electrospun scaffold was prepared from a nanohydroxyapatite/ polymer blend in the present study. Viscosity of n-HA/PEA compound solution determined by PEA concentration and additives of n-HA was investigated while other parameters were fixed in the electrospinning process. The fiber diameter increased with the increasing viscosity of solution. 20wt% n-HA in the composite ultrafine fibrous scaffold was proved to be a preferable ratio. The n-HA/PEA scaffold was characterized by XRD, SEM and EDX. The fibrous electrospun scaffold, which is made up of ultrafine fibers with average diameter 400±50 nm and well-interconnected pores, was characterized with high surface–to-volume ratio, which is conducive to cell and tissue growth. A comparatively uniform distribution of n-HA crystals in a single fiber even in the whole scaffold was confirmed by EDX. The biocompatibility of the composite was investigated by culturing osteobalsts on the scaffold. Good cell adhesion and proliferation manner was observed on the fibrous scaffold by SEM and MTT assay. It could be expected that the electrospun HA/PEA composite scaffold would be a potential biomimetic extracellular matrix biomaterial for bone tissue engineering.
Authors: Lan Lei Wang, Ji Hua Li, Yong Tao Xie, Pi Shan Yang, Yun Mao Liao, Gong Ling Guo
Abstract: The aim of the present study is to investigate the efficacy of nanobiphasic calcium phosphate (nanoBCP) bioceramic in the treatment of periodontal osseous defects. Alveolar bone defects were surgically created bilaterally at the buccal aspects of four second premolars in two beagle dogs. After root leveling, nanoBCP was randomly filled in one defect and nothing was put into the contralateral defect as negative controls. Bioglass was randomly filled in one of left defect as positive controls and nothing was put into the contralateral defect as negative controls. Dogs were killed at the 12th week. Histological observations were processed through a light microscopy. The results reveal that a great amount of functional periodontal fissures formed in the defects in the nanoBCP groups and bioglass groups while no new bone formed in the control groups at all. In this study, nanoBCP has proven to work well as a biocompatible and bioactive material to promote periodontal regeneration effectively.
Authors: Y.H. Yu, F. Xiong, Z.M. Zhu, Yun Mao Liao, Zhong Rong Zhou
Abstract: The erosion of dental glass infiltrated aluminum ceramics by sandblasting was evaluated. The variations of wear depth, surface roughness and bending strength after blasting were of particular interest. The sandblasting parameters of working pressures, times and erodent size came from routine manufacturing procedures. The results showed the erodent size affects the bending strength and pressure affects mainly the wear depth. The surface roughness increased significantly after sandblasting, but the differentiations with various blasting parameters were not apparent. Fatigue cracking characterized the mechanisms of erosion of dental glass infiltrated ceramics.
Authors: Fang Fang Wang, Yun Mao Liao, Min Wang, Ping Gong, Xiao Yu Li, Hua Tang, Yi Man, Quan Yuan, Na Wei, Zhen Tan, Yu Ban
Abstract: In this study, an exclusive sodium titanate (Na2Ti6O13) coating on titanium was fabricated by sol-gel method and evaluated in vitro. The coating was characterized by SEM and XRD. The bioactivity of the Na2Ti6O13 coating was evaluated by the biomimetic growth of apatite on its surface after soaked in an acellular simulated body fluid (SBF) for a period of time. In vitro osteoblasts culture was carried out to determine cytocompatibility by the measurement of the proliferation and alkaline phosphatase (ALP) activity of the cells. XRD patterns showed that Na2Ti6O13 was well crystallized when the coating was heated at 800°C. SEM observation exhibited that the Na2Ti6O13 coated titanium had a homogeneous surface without any cracks. After immersion in SBF, the apatite layer can be formed on the coating. The cells culture showed that the osteoblasts grew well on the Na2Ti6O13 coated titanium. It can be concluded that Na2Ti6O13 coating on titanium obtained by sol-gel method is bioactive.
Authors: W.C. Chen, C.Y. Bao, Y.L. Jeyachandran, Guo Min Ou, Hong Song Fan, Yun Mao Liao, Xing Dong Zhang
Abstract: Circumambient tissues infection is a common complication of implanted percutaneous and permucosal devices (PDs). In order to counter the infection, the titanium abutment surface of PDs was modified to achieve antibacterial and antiadhesive activities. Titanium discs were immersed into hydroxyapatite (HA) sol containing different mass fraction silver and thermally treated to get modified discs. The modified discs become more smoother and get crystal HA coatings containing silver. Silver ion release test demonstrate the release rate is very slow and the coating is a reservoir of silver. The antibacterial and antiadhesive effects of modified discs on Staphylococcus aureus and Porphyromonas gingivalis were evaluated. Modified titanium discs with silver significantly inhibited the growth of these two bacteria compared with both the polished titanium discs control and modified titanium discs without silver. And titanium discs modified with more silver have higher antibacterial activity and less bacteria adhesion in this study. These findings indicate that titanium surface modified with the HA sol-gel containing silver could achieve antibacterial and antiadhesive activities, and the abutments of PDs are promising to be modified by this method.
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