Papers by Author: Hui Chuan Zhao

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Authors: Yu Mei Xiao, Hui Chuan Zhao, Hong Song Fan, Xin Lin Wang, L.K. Guo, Xu Dong Li, Xing Dong Zhang
Abstract: A composite of needle-like nano-hydroxyapatite (n-HA)/poly (D,L) lactide (PDLLA) was prepared. The n-HA crystals were poorly crystallized and uniformly distributed in the composite with a crystal size of 10–20 nm in diameter by 40–60nm in length,which was smaller than that of pure nano-HA. Molecular interactions and chemical bonds might present between n-HA and PDLLA in the composite, which were revealed by IR and XPS. The synthetic n-HA/PDLLA composite had a good homogeneity and could be a bioactive material for bone defect especially for load-bearing bone repair, which is more potential than pure HA or pure PDLLA.
Authors: Xiu Dong Yang, Min Tang, Bo Zhang, Hui Chuan Zhao, Xing Dong Zhang, Ji Yong Chen
Abstract: Bonelike apatite coating on metal implants is an effective method to enhance bioactive properties of the metal surface. In the present study, the effectiveness of cathode deposition (CD) coating methods was investigated. And biomimetic deposition (BD) was also investigated as the parallel. The revised simulated body fluid (R-SBF) was chosen as an electrolyte and simulated body fluid. Both deposition methods could produce bonelike apatite coating on rough surfaces of the titanium. The uniformity of the CD coatings were better than the BD coatings’. And CD method was less sensitive to the condition of the titanium plate surfaces and much faster in the coating deposition. The spectra of FTIR showed that the characteristic peaks of CO3 2- apeared on the surface of ceramics, combined with spectra of XRD and SEM, it was concluded that a sertain thickness of bonelike apatite coating could be formed on the acided treatment (AT) titanium plate surfaces by CD method.
Authors: Xiao Liang Wang, Xu Dong Li, Xiao Min Wang, Jian Lu, Hui Chuan Zhao, Xing Dong Zhang, Zhong Wei Gu
Abstract: Collagen (Col) and chitosan (Chi) are both natural polymers and have received extensive investigation in recent years in the field of tissue engineering, but there are few reports on the introduction of hydroxyapatite (HA) into the Col-Ch system. In this study, based on the miscibility of these two polymers under proper condition, hydroxyapatite (HA) was synthesis in the Col-Chi system by in-situ co-precipitate method to give rise to a novel nanocomposite. The structural characterization of such Col-Ch-HA nano-materials was carried out by using FT-IR, XRD, SEM and TGA analyses with main components and Col-Chi samples used for comparison. It was found that there exist interactions between Col and Chi molecules. The nucleation and growth of inorganic phase occurs in the Col-Chi system and final products are uniform dispersion of nano-sized HA in the Col-Chi network without obvious phase separation. This novel nanocomposite would be a promising material for bone tissue engineering.
Authors: Qing Rong Wei, Jian Lu, Hui Chuan Zhao, Bo Jiang, Bo Zhang, Zhong Wei Gu, Xing Dong Zhang, Ji Yong Chen
Abstract: In order to develop a bone-filling material with osteoinductive potential, a composite micorspheres of collagen molecules and biphasic calcium phosphate (BCP) was prepared by utilizing emulsion polymerization and the intrinsic self-assembly of collagen. The prepared microspheres were analyzed by granularity test, scanning electron microscopy (SEM), infrared spectra (IR) and enzymatic digestion experiment. The results showed that the collagen matrix of fibrils was reconstituted in the droplets, and the native triple-helix structure of collagen was still maintained. The study provides an effective way to prepare microspheres of collagen and BCP composite.
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