Papers by Author: M.A. Lopes

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Authors: A.G. Dias, M.A. Lopes, Kanji Tsuru, Satoshi Hayakawa, José D. Santos, Akiyoshi Osaka
Abstract: This work reports the structure of two glass ceramics prepared in the calcium phosphate system, MK5B and MT13B, using 31P MAS-NMR technique. The results obtained showed that the network of MK5B consisted mainly of Q1 and Q2 groups. Besides these two groups, MT13B material also present Q3 units. The Qn groups detected in both glass ceramics seem to be correlated to the crystalline phases present in their microstructure.
Authors: G. Pavan Kumar, A. Jaya Kumar, P. Krishnanjaneya Reddy, Sooraj Hussain Nandyala, M.A. Lopes, José D. Santos
Abstract: Bony defects caused by periodontitis are often treated by regenerative therapy using autografts and/or allografts. Alloplasts such as hydroxyapatite or ceramics and bioactive glasses are used as osteoconductive materials that serve as scaffold for new bony ingrowth. The purpose of this study was to ascertain the possible regenerative capability of glass reinforced hydroxyapatite (Bonelike¬)¬¬¬ an osteoconductive synthetic graft in the treatment of human periodontal intrabony angular defects. The material was placed in 2 defects in 2 individual patients and clinical parameters such as probing depth (PD) and clinical attachment level (CAL) have been included. Bone fill was determined using an intra oral periapical radiograph (IOPA) and Autocad Software. After 3 months implantation period, there was an improvement in CAL and reduction in PD along with bone fill was observed.
Authors: J.V. Lobato, Nandyala Sooraj Hussain, C.M. Botelho, J.M. Rodrigues, A.L. Luís, Ana Colette Maurício, M.A. Lopes, José D. Santos
Abstract: BonelikeÒ graft that mimics the inorganic composition of bone tissue has been developed and characterized over the last decade. To evaluate the osteoconductivity of BonelikeÒ two granule size ranges, one ranging from 150-250µm and the other from 250-500µm were implanted in the femurs of New Zealand White rabbits, aiming at being clinically used in different medical applications, such as dentistry and orthopaedics. In order to facilitate the medical application of the BonelikeÒ graft the use of a commercially available polymeric vehicle was also analyzed. Radiological examination, histological studies and scanning electron microscopy (SEM) analyses revealed that the surface of Bonelike® granules was almost completely surrounded by new bone formation after 12 weeks of implantation, which proves its highly osteoconductive behaviour.
Authors: A.G. Dias, M.A. Costa, M.A. Lopes, José D. Santos, Maria Helena F.V. Fernandes
Authors: C.M. Botelho, Roger A. Brooks, Serena Best, M.A. Lopes, José D. Santos, Neil Rushton, William Bonfield
Authors: M. Gutierres, Nandyala Sooraj Hussain, A. Afonso, L. Almeida, T. Cabral, M.A. Lopes, José D. Santos
Abstract: This paper reports the ability of Bonelike® to regenerate bone defected areas when implanted in the tibia of 3 patients (average age of 59 years) during a high tibial osteotomy (HTO) to treat medial compartment osteoarthritis of the knee. Bonelike® is a synthetic bone graft designed to mimic the inorganic composition of bone using a patent process that consists of liquid sintering hydroxyapatite in the presence of CaO-P2O5 based glass. The preliminary clinical evaluation performed showed that an intimate contact between new formed bone and Bonelike® was established (67±10 %), with no fibrous interface. Therefore, Bonelike® is a single-handedly viable osteoconductive synthetic grafting material as it has been demonstrated from the profiles of radiological, histological and scanning electron microscopy analyses for the six months implantation period.
Authors: J. Miguel Oliveira, Takahiro Kawai, M.A. Lopes, Chikara Ohtsuki, José D. Santos, A. Afonso
Authors: C.M. Botelho, D.J. Stokes, Roger A. Brooks, Serena Best, M.A. Lopes, José D. Santos, Neil Rushton, William Bonfield
Authors: Yanbao Li, Wen Jian Weng, Kui Cheng, Pi Yi Du, Ge Shen, Gao Rong Han, M.A. Lopes, José D. Santos
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