Papers by Author: Mitsuhiro Hibino

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Authors: Seiji Yamaguchi, Takeshi Yabutsuka, Mitsuhiro Hibino, Takeshi Yao
Abstract: Apatite pattern was prepared by electrophoretic deposition (EPD) transcribing resist pattern. A porous polytetrafluoroethylene (PTFE) film was used as a substrate and attached on a cathode. The cathode for EPD was stainless plate with resist pattern. EPD was performed with a suspension of wollastonite particles in acetone and wollastonite particles were deposited on the substrate in the form of the resist pattern. When the wollastonite-deposited substrate was soaked in simulated body fluid (SBF), apatite was induced and then replaced wollastonite at the wollastonite deposited region on the substrate. As a result, apatite was formed in the pattern that traced the resist pattern. The minimum line width of the apatite pattern was about 100 µm.
659
Authors: Hidetaka Okada, Seiji Yamaguchi, Mitsuhiro Hibino, Takeshi Yao, Shin Hasegawa, Masashi Neo, Takashi Nakamura
Abstract: Apatite micropattern was fabricated by a combination of biomimetic process and transcription of resist pattern. We optimized some fabrication conditions such as the height of resist pattern, temperature, concentrations and pH of simulated body fluid(SBF). Consequently, we successfully obtained apatite micropattern widely and homogeneously on a substrate in a short fabrication period.
663
Authors: Koji Sato, Daisuke Onodera, Mitsuhiro Hibino, Takeshi Yao
Abstract: Poly methyl methacrylate(PMMA) with mar resistant or poly ethtylene(PE) substrates were surface-treated by applying plasma discharge or alkaline solution. Ceramic thin film comprised of silicon oxide, titanium oxide and zirconium oxide was formed on these surface treated substrates respectively from an aqueous solution, and after the formation of ceramic thin film, titanium oxide thin film was also coated on them from aqueous solution at ordinary temperature and pressure. The thin film coated polymer material was tested in mechanical property. The thin film was hard and the adhesion strength to the organic polymer substrate was very high. The substrate was soaked in SBF and apatite was formed on the substrate. This method is promising for developing hard and soft tissue implants with various mechanical properties as well as high bioactivity.
771
Authors: Takeshi Yabutsuka, Seiji Yamaguchi, Mitsuhiro Hibino, Takeshi Yao
Abstract: By electrophoretic deposition, wollastonite particles were deposited in pores of porous ultrahigh molecular weight polyethylene (UHMWPE). The UHMWPE-wollastonite composite thus fabricated was soaked in a simulated body fluid. As a result, apatite was formed inside the pores as well as on the surface of the UHMWPE-wollastonite composite. The formed apatite showed high adhesive strength to the composite.
1177
Authors: Takeshi Yabutsuka, Seiji Yamaguchi, Mitsuhiro Hibino, Takeshi Yao
Abstract: Apatite nuclei were precipitated in the pores of the porous polyethylene matrix in 2.0SBF. Apatite was induced by the apatite nuclei inside the pores and on the surface of the composite and grew to the surface of the composite by a soak in 1.0SBF. The formed apatite showed high adhesive strength to the composite probably due to a mechanical interlocking effect between the matrix and the apatite.
467
Authors: Takeshi Yabutsuka, Mitsuhiro Hibino, Takeshi Yao
Abstract: Apatite nuclei were precipitated in the pores of titanium in simulated body fluid (SBF) and titanium-apatite nuclei composite was obtained. Apatite was induced by the apatite nuclei inside the pores of the composite and apatite layer was formed on the composite surface by soaking in SBF. The apatite layer showed high adhesive strength to the composite due to a mechanical interlocking effect between the composite and the apatite.
709
Authors: Takeshi Yabutsuka, Yuzo Inoue, Masayuki Shimada, Mitsuhiro Hibino, Takeshi Yao
Abstract: Apatite nuclei were dispersed in inorganic binder and the apatite nuclei-contained inorganic binder was coated on polyethyleneterephthalate plate. Hydroxyapatite was induced by the apatite nuclei dispersed in the binder and hydroxyapatite layer was formed on the surface of the substrate by soaking in SBF. The hydroxyapatite layer showed high adhesive strength to the substrate.
433
Authors: Takeshi Yabutsuka, Shinichiro Tsuboi, Mitsuhiro Hibino, Takeshi Yao
Abstract: Apatite nuclei were synthesized by raising pH of simulated body fluid (SBF). The apatite nuclei were attached to surfaces of Ag microspheres. Hydroxyapatite (HAp) was induced from the apatite nuclei and spread over whole surface area of the Ag microspheres in SBF, then encapsulated Ag microspheres with HAp were fabricated. The encapsulated Ag microspheres with HAp were soaked in saline and changes in Ag ion concentration in saline were measured. The encapsulated Ag microspheres with HAp showed sustained-release of Ag ion.
1199
Authors: Shihori Yamane, Takeshi Yabutsuka, Mitsuhiro Hibino, Takeshi Yao
Abstract: Apatite nuclei were precipitated in the pores of silicagel microspheres by raising pH of simulated body fluid (SBF). By a soak in SBF, hydroxyapatite (HAp) was induced from the apatite nuclei and spread over whole surface area of the silicagel microspheres. Then encapsulated silicagel microspheres with HAp were fabricated.
519
Authors: Yasuhiro Tabe, Mitsuhiro Hibino, Takeshi Yao
Abstract: Apatite nuclei were synthesized by raising pH of simulated body fluid (SBF). Poly (lactic acid) (PLA) microspheres were soaked in apatite nuclei suspension, and then apatite nuclei were attached to surfaces of the PLA microspheres. When these PLA microspheres were soaked in SBF, apatite nuclei on the PLA microspheres induced HAp. As a result, PLA microspheres coated with HAp were fabricated. The HAp-coated PLA microspheres were soaked in acetone. The PLA core was dissolved out, and then consequently hollow microcapsules constructed of HAp were fabricated. As HAp microcapsules have properties of bioaffinity and non-toxicity, they were expected to be applicable to an excellent carrier of drug delivery system.
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