Papers by Author: Sakdiphon Thiansem

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Authors: Sittiporn Punyanitya, Rungsarit Koonawoot, Anucha Ruksanti, Sakdiphon Thiansem, Anirut Raksujarit, Watchara Sontichai
Abstract: Biodegradable scaffold is an accepted and commercialized medical alternative choice for bone regeneration. In this project, we used our new invention, porous starch-Hydroxyapatite (HA) composite for in vivo clinical trial. The products were prepared from medical grade Thai rice starch mixed with high purity (>97%) HA powder from fresh cow bone, and already passed in vivo animal biocompatibility test, then processed by freeze-drying. There were 44 volunteers from orthopedic and neurosurgical division, 4 and 40 patients, respectively. The results were assessed by operative surgeons and nurses, pre-and intraoperative period, including size appropriateness, comfort handle, ease of cutting, void space filling, water stability, product weight, shelf storage, package opening, contamination risk and waste removal. All average satisfactory scales were more than 95% rating. For postoperative period, at least 6 months, the soft tissue swellings around surgical areas were resoluted about 3 days as usual healing process. There were no any symptoms or signs of infection or allergic reactions. The follow up of x-ray imaging showed well ossification about 2 months. All patients have gained good functional performance. So porous starch-HA composites biomaterial can be used for human bone and skull regeneration with completely safety and efficacy.
Authors: Sittiporn Punyanitya, Rungsarit Koonawoot, Sakdiphon Thiansem, Surasit Laosatirawong, Anirut Raksujarit
Abstract: The main objective of this work is to make an absorbable monofilament suture from Thai rice starch. The improvement of the mechanical properties of Thai rice starch polymer films were achieved by addition of small amount of gelatin, carboxymethylcellulose (CMC) and carbon nanopowders. The carbon nanopowders were produced from coconut shell in our laboratory room by milling method. The incorporation of carbon nanopowders with a high aspect ratio and/or an extremely large surface area into Thai rice starch polymer films improves their mechanical performances significantly. Additionally, the black color from carbon nanopowder is easily visualized in tissue during surgery. The manufacturing processes are very simple by blending of the raw materials in hot water and then dry heating in electric oven. The final product was characterized of microstructures and mechanical properties. The resulting Thai rice starch-carbon nanocomposites possess several advantages for manufacture of sutures: 1. high water resistance that can be uses in the human body. 2. high mechanical strength that appropriate to manufacture of sutures. 3. biocompatibility and bioabsorbable. 4. low cost. 5. Eco-friendly green nanocomposites. However, the method of size designation of sutures fibers and needle attachment are the problem which restricts our suture in really applications. The investigation of knowledge and simple technology of manufacture of suture and needle attachment will be performed.
Authors: S. Janta, S. Watanesk, R. Watanesk, Sakdiphon Thiansem
Abstract: In this study, the uptake of fluoride by raw diatomite and diatomite activated by heat treatment was investigated. Influential parameters such as contact time, pH and adsorption isotherm were also studied. The results showed that the diatomite heated to 500 oC performed better than other heat treatment products and the equilibration time needed for fluoride removal by the adsorbents was reached at 60 min. Results revealed that the capacity of the adsorbents for removing fluoride is independent of the pH when the pH is higher than 4. The adsorption isotherm of the 500 oC treated diatomite showed its Langmuir behavior. The maximum adsorption capacity of raw diatomite and 500 oC calcinated diatomite are 2.253 and 4.162 mg/g, respectively. Based on the results it can be concluded that the diatomite appears to be an economical and environmentally friendly material for defluoridation of water.
Authors: Rungsarit Koonawoot, Cherdsak Saelee, Sakdiphon Thiansem, Sittiporn Punyanitya
Abstract: Hydroxyapatite (HA) is widely used in bioceramic materials for bone grafting. HA scaffolds were synthesized using solid-state reaction method. Scaffolds were prepared by milling the elements of CaCO3 and NH4H2PO4 powders. The obtained powder was pressed with uniaxial pressing into a disc shape with the dimension of 4 mm in thickness and 16.5 mm in diameter under pressures 3 MPa and then sintering the samples at difference temperatures from 1100°C to 1300°C for 3 hours. This research aimed to produce phase HA scaffolds in order to find out the effects of sintering temperature on phase contents, density, porosity, hardness and bending strength, and to use optimized condition samples study with laboratory rats’ soft tissue to evaluate the soft tissue response to the samples. Thirty-two healthy in adults’ on non-gender-specific of Wistar rats were used in this study. Optimized, sintered samples were cut and lathed into a cylindrical shape. Sixty-four samples of optimized condition were implanted and left in subcutaneous tissue for 3, 7, 14, 21, 30, 45, 90 and 180 days. XRD, XRF, Archimedes technique, Vickers hardness and bending strength, as well as light microscopy, were used for analysis. The results of optimized condition have shown the bodies of sintered sample at 1300 °C for 3 hours had the highest content of 91.02 % HA phase, and the remaining phases of 4.51 % b-TCP and 4.47 % CaO, its bulk density and strength increased with increasing temperature, the highest bulk density of 2.006 ± 0.033 g/cm3, hardness of 30.02 ± 3.23 HV, bending strength of 9.07 ± 1.15 MPa. Sample reactions to soft tissues at 180 days were mild inflammatory cells, an absence of cellular infiltration, a presence of calcification, and absence of displacement of ceramic components into surrounding host tissue. Our results concluded that the samples were nontoxic to subcutaneous tissue and biocompatibility
Authors: Rungsarit Koonawoot, Cherdsak Saelee, Sakdiphon Thiansem, Sittiporn Punyanitya
Abstract: This work reports the influence of chemical composition and sintering schedule on the properties of sintered bodies of hydroxyapatite (HA) bioceramic. The method of preparing sintered bodies by solid state reaction and uniaxial pressing. The raw material used calcium carbonate (CaCO3) and ammonium dihydrogen phosphate (NH4H2PO4) powder as precursors. These powders were mixed at CaCO3: NH4H2PO4 mass ratio of 1:0.697, 1:0.692, 1:0.689, 1:0.685 and 1:0.68, respectively. The compositions in the temperatures range of 800-1300 °C for 3 hour. The sintered bodies were characterized by X-ray diffraction (XRD), scanning electron microscope (SEM), and Fourier transform infrared spectroscopy (FTIR). Properties including phase, microstructures, porosity and bending strength of the samples. The results show that green bodies can be sintered at 1150 °C for 3 hours. This temperature found that crystals growth, highest of HA phase content in sintered bodies, good density and high efficiency strength properties.
Authors: Phanlob Chankachang, S. Chantara, Sittiporn Punyanitya, Cherdsak Saelee, Sakdiphon Thiansem
Abstract: Nanocomposite filters were prepared by sintering of hydroxyapatite (HA) and Lampang clay composite nanopowder. 50 wt% amount of Lampang clay nanopowder are incorporated into HA nanopowder. The mixing powders are uniaxially compact and then sintering at 900°C-1050°C in air. The bending strength tests were performed and microstructure characterizations were carried out by scanning electron microscopy and mercury porosimetry analysis in order to determine the optimum sintering conditions. Filtration studies using optimized filter were performed for rubber wastewater. The results from this work clearly show that nanocomposite filter is an efficient and ecologically suited environmental technology for decontamination of the wastewater generated from rubber processing.
Authors: Surasit Laosatirawong, Sakdiphon Thiansem, Sittiporn Punyanitya
Abstract: Characterization of Environmentally friendly materials used as wastewater treatment material has been studied in order to compare the quality of wastewater in Chiang Mai, Thailand on two types of treatment materials, which are cow bone char (CBC) made from Thai cow bone char cleaned and calcined at 850๐C and the a mineral called “zeolite” (ZLT) bought from Kamthiang market, Chiang Mai. The physical characteristics of both types of materials indicate that the CBC has a higher density than the ZLT but has lower pore volume than the ZLT. The effect of density on the water quality improvement was showed that CBC was a suitable type of wastewater treatment material because their high density can fix them in the batch system.
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