Papers by Keyword: Bioactive Glass

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Authors: Viviane Gomide, Natália Ocarino, Rogéria Serakides, Maria de Fatima Leite, Marivalda Pereira
Abstract: Bioactive glass/polymer hybrids are promising materials for biomedical applications because they combine the bioactivity of these bioceramics with the flexibility of polymers. In previous work hybrid foams with 50% bioactive glass and 50% polyvinyl alcohol (PVA) were prepared by the sol-gel process for application as scaffold for bone tissue engineering. In this work the hybrid samples were tested in osteoblast culture to evaluate adhesion and proliferation. Samples were also implanted subcutaneously in the dorsal region of adult rats. The hybrid 50% PVA/bioactive glass foam was chosen as the best scaffold in the composition range studied and it is a promising material for bone repair, providing a good environment for the adhesion and proliferation of osteoblasts in vitro. Concerning the in vivo studies we can assure that the “foreing body” reaction was moderate and that the presence of osteoid indicated bone matrix formation.
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Authors: Sunil Prasad, Vikas Kr Vyas, Md Ershad, Ram Pyare
Abstract: Bio-glass® and hydroxyapatite (Ca10 (PO4)6(OH) 2, HA) has been widely used as a bone replacement material in restorative dental and orthopedic implants. In order to analyze in vitro bioactivity bio-composite before and after exposed to simulated body fluid (SBF) solution for different time periods were investigated by fourier transform infrared (FTIR) reflectance spectrometer with measuring the pH and concentration of silicon, sodium, calcium, phosphorus and manganese ions in SBF solution. The prepared bio-composites were assessed by XRD, FTIR, mechanical properties. FTIR confirmed the presence of a rich bone like apatite layer post-immersion on the composite surface. It has been found that the new BG/HA bio-composite materials have high bioactivity properties. These bio-composite materials are promising for medical applications such as bone substitutes.
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Authors: Criseida Ruiz-Aguilar, E.A. Aguilar-Reyes, Ana Edith Higareda-Mendoza, C.A. León-Patiño
Abstract: Bone tissue engineering is an excellent alternative to reduce bone disorders and conditions, by inducing new functional bone regeneration starting from the synthesis of the biomaterials and then the combination of cell and factor therapy. In the present contribution, the scaffolds were made with a ratio of 80 wt.% of β-TCP and 20 wt. % of phosphate-based bioglass, in addition the phosphate-based bioglass was reinforced with zirconia in different amounts (0, 0.5 and 1.0 mol%) with the aim to reduce the dissolution rate, improve the osteoconduction and the osteogenesis of the bone tissue. The results obtained by μCT of the scaffolds containing zirconia showed a wide pore size distribution between 1.5 and 303 μm. AlamarBlue assays showed that the cell proliferation of MC3T3-E1 preosteoblasts scaffolds were sixfold increase in relation to the number of the initial cells. FE-SEM helped to observe the cauliflower structure of HA and DRX showed that crystalline phases formed after heat treatment were (NaCaPO4 and NaZr5PO4) owing both to the crystallization and combination of the bioglass and β-TCP .
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Authors: Mehdi Mehdikhani-Nahrkhalaji, Mohammad Hossein Fathi, Vajihesadat Mortazavi, Sayed Behrouz Mousavi, Batool Hashemi-Beni, Sayed Mohammad Razavi, Ali Akhavan, Abbas Haghighat
Abstract: The aim of this study was to evaluate the interaction of bioactive and biodegradable poly (lactide-co-glycolide)/bioactive glass (PBG) nanocomposite coating with bone and human adipose-derived stem cells (hASC) in vivo and in vitro, respectively. Sol-gel derived 58S bioactive glass (BG) nanoparticles and 50/50wt% poly (lactic acid)/poly (glycolic acid) (PLGA) were used to prepare the coating. The nanocomposite coating was characterized by SEM, XRD, and AFM. Mechanical stability of the prepared nanocomposite coating was studied during intramed­ullary implantation of coated Kirschner wires (k-wires) into rabbit tibiae. Titanium mini-screws coated with PBG nanocompoite coating was implanted intramedullary in rabbit tibia. Bone tissue interaction with the prapared nanocomposite coating was evaluated 30 and 60 days after surgery. The effect of PBG nanocomposite coating on the attachment and viability of human adipose-derived stem cells (hASCs) was investigated. Results showed that PBG nanocomposite coating remained stable on the K-wires with a minimum of 96% of the original coating mass. Tissue around the coated implants showed no adverse reactions to the coating. Woven and trabecular bone formation were observed around the coated samples with a minimum inflammatory reaction. The hASCs showed excellent attachment and viability on the PBG nanocomposite coating. It was concluded that PBG nanocomposite coating provides an ideal surface for bone formation and stem cells attachment and it could be used as a candidate for coating the dental and orthopedic implants.
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Authors: S. Loty, J.M. Sautier, C. Loty, M.T. Tan, D.C. Greenspan, N. Forest
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Authors: Ourania Menti Goudouri, Eleana Kontonasaki, Nikolaos Kantiranis, Xanthippi Chatzistavrou, Lambrini Papadopoulou, Petros Koidis, Konstantinos M. Paraskevopoulos
Abstract: Melt derived bioactive glass- porcelain system is reported to be bioactive but with a slow rate of bioactivity. The aim of this work is to fabricate and characterize bioactive glass/dental porcelain composites produced by the sol-gel method. Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM) and X-ray Diffractometry (XRD) were used to characterize the fabricated materials. The FTIR spectra and the XRD patterns confirm the presence of both constituents in the mixtures, while the dominant crystal phases in bioactive glass/dental porcelain specimens are leucite and wollastonite.
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Authors: Gigliola Lusvardi, Ginaluca Malavasi, Ledi Menabue, Maria Cristina Menziani
Abstract: This review presents a combined experimental-computational strategy for the development of potential bioactive zinc–containing silicate glasses and shows how sound relationships among the structural role of some key elements that appear to control bioactivity can by established and exploit for rational glass design.
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Authors: S.S. Seyedmomeni, M. Naeimi, Majid Raz, J. Aghazadeh Mohandesi, F. Moztarzadeh
Abstract: Various kinds of bioactive materials are developed as bone substitutes. Bioactive materials may affect attachment, proliferation and differentiation of cells and the subsequent integration in a host tissue. In this research 21%CaO–5%P2O5–64%SiO2–5%ZnO-5%B2O3 and 16%CaO–5%P2O5–64%SiO2–5%ZnO-10%B2O3 bioactive glasses were successfully synthesized by the sol–gel technique. Then the prepared bioactive glasses were soaked into simulated body fluid. Then the prepared samples were characterized using X-ray diffraction (XRD) and Scanning electron microscopy (SEM). It was seen that addition of boron to the structure remarkably enhances the formation of hydroxyapatite on the surface of the bioactive glass and subsequently improves the bioactivity. The obtained results from SEM and XRD were in good agreement with each other. Besides, effect of boron on atomic arrangement of the prepared bioactive glass was studies and compared with previous researches. It was shown that by increasing the boron content, more crystalline domains would be observed.
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Authors: Larry L. Hench, Julia M. Polak
Abstract: Historically the function of biomaterials has been to replace diseased, damaged and aged tissues. First generation biomaterials, including bio ceramics, were selected to be as inert as possible in order to minimize the thickness of interfacial scar tissue. Bioactive glasses provided an alternative from the 1970’s onward; second generation bioactive bonding of implants with tissues and no interfacial scar tissue. This chapter reviews the discovery that controlled release of biologically active Ca and Si ions from bioactive glasses leads to the up-regulation and activation of seven families of genes in osteoprogenitor cells that give rise to rapid bone regeneration. This finding offers the possibility of creating a new generation of gene activating bioceramics designed specially for tissue engineering and in situ regeneration of tissues.
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Authors: M. Bellantone, N.J. Coleman, Larry L. Hench
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