Papers by Keyword: Polycaprolactone

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Authors: Mehmet Onur Aydogdu, Nazmi Ekren, Osman Kilic, Faik Nüzhet Oktar, Oguzhan Gunduz
Abstract: In this present work, an original 3D bioprinting method has been developed by modifying an exceptional 3D printer. Using a composite material, bioprinting was carried out to create the ideal scaffold material to contribute regeneration of the certain amount of tissue types in humans. After bypassing the extruder and heating system of the 3D printer, instead of using solid filaments, polymer-ceramic composite was dissolved using an organic agent and bioprinting was conducted. During the bioprinting, dissolving agent was evaporated quickly and solidification process was completed. Despite of the traditional 3D printing, which benefits from the glass transition temperature of the materials, regardless of the temperature, rapid prototyping technology has been merged with controlled flow rate of the composite solution and evaporation of the solvents were adjusted meticulously for proper solidification and layer by layer bioprinting of the scaffolds.
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Authors: Ho Hyun Song, Mi Kyong Yoo, Hyun Seuk Moon, Yun Jaie Choi, Hyun Chul Lee, Chong Su Cho
Abstract: In this study, novel polycaprolactone/hydroxyapatite (PCL/HA) scaffolds were prepared to increase mechanical properties and degradation of PCL/HA ones for bone tissue engineering. PCL macromers were synthesized through the reaction of PCL diol (Mn: 530, 1250, and 2000) and PCL triol (Mn: 900) with acryloyl chloride and confirmed using nuclear magnetic resonance spectrometer (NMR) and fourier transform infrared (FTIR). The PCL/HA scaffolds were prepared by cross-linking of PCL macromer in the presence of HA by UV treatment and freeze drying methods. Mechanical property and porosity as well as degradability of the PCL/HA scaffolds were also investigated. PCL/HA scaffolds showed faster degradation and higher compressive modulus than those of PCL itself due to their low crystallinity and modification of terminal groups. The pore morphology and pore sizes of the PCL/HA scaffold were checked by scanning electron microscope (SEM). Cell cytotoxicity and proliferation of MG-63 osteoblast cultured onto the PCL/HA scaffold was assessed by lactate dehydrogenase (LDH) assay and Alamar blue assay, respectively. The novel PCL/HA scaffold appears to be suitable for bone substitutes.
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Authors: A. Liu, J. An, Chee Kai Chua, Kah Fai Leong
Abstract: Engineered tendon and ligament scaffolds are ideally a bunch of biocompatible and biodegradable microfibers that are three-dimensionally aligned with no fusion between individual fibers. In this paper, a simple yet effective device that is able to fabricate this nearly native structure is presented, including design and operation method. Briefly, the device is die-free and requires only simple components such as a plate with an orifice, an aluminum holder, a ring heater and a rotating mandrel. The fabrication is done by a single step with microfiber (10 µm diameter) bundles being directly obtained at a very low take-up speed. The as-spun microfiber bundles appear silvery and shiny, apparently similar to a native tendon. This device and the method associated opens up a new way to diversify the structure of biomaterials.
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Authors: Rabiatul Manisah Mohamed, Kamal Yusoh
Abstract: The concept of biodegradable plastics is of considerable interest with respect to solid waste accumulation. Greater efforts have been made in developing degradable biological materials without any environmental pollution to replace the traditional plastics. Among numerous kinds of degradable polymers, polycaprolactone sometimes called PCL, an aliphatic polyester and biocompatible thermoplastic, is currently a most promising and popular material with the brightest development prospect and was considered as the ‘green’ eco friendly material. The application for this biodegradable plastic includes controlled drug releases, tissue engineering, bone scaffolds, packaging and, compost bags etc. This review will provide information on current PCL development, material properties of PCL and its composites, and also its wide spectrum applications.
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Authors: Maria Mucha, Iwona Socha-Michalak, Jacek Balcerzak
Abstract: In the paper the results of control drug release from different forms of carriers are presented. Dibutyrylchitin, chitosan, polylactid acid and polycaprolactone have been used as matrices for delivery of therapeutic substances (ibuprofen and salicylic acid). Two configurations of matrices for drug delivery have been found. Flat drug delivery systems (films) and spherical matrices (beads) were tested in the aim of control drug transport. To control the drug release, matrices have been modified. The release of active substances from films has been tested in buffer solution of pH 5.5. Spherical matrices have been tested in buffer solutions of pH 1.4 and pH 7.2. To experimental data First order and two stage models were fitted.
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Authors: M. Ngiam, T.R. Hayes, S. Dhara, B. Su
Abstract: Chemical treatment of polycaprolactone was carried out to bioactivite the biodegradable polymer for bone tissue engineering application. The results show that surface modifications are necessary to introduce functional groups such as carboxylic groups for the effective induction of apatite nucleation, prior to SBF treatment. The functional groups, acting as anchors between the polymer and the apatite nuclei, dictate the duration of the induction period need for apatite nucleation. After the surface treatment with sodium hydroxide solution, the apatite nuclei will form and grow spontaneously into a dense and uniform layer of apatite, by taking up Ca2+ and PO4 2- ions that are present in the SBF, as SBF is supersaturated with respect to apatite. Similar surface treatment was applied to electrospun PCL nanofibres. Biomimetic apatite/PCL nanofibres were formed which can potentially be used as bone tissue engineering scaffolds.
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Authors: Wen Zhu Ouyang, Yong Huang
Abstract: In this study, cellulolytic enzyme lignin (CEL) was blended with polycaprolactone (PCL) by twin-screw extrusion and injection molding. The thermal, mechanical properties and the morphology of the PCL/CEL blends were investigated as a function of CEL content. The results showed that the CEL in the blends acting as nucleus accelerated the crystallization of PCL when CEL was not more than 10 wt%, but retarded PCL to crystallize with more CEL addition. Thermogravimetry analysis (TGA) revealed that the thermal stability of the PCL/CEL blends was almost unaffected by increasing CEL content. Mechanical test showed that, although the elongation at break and the impact strength were decreased, the strength and the modulus of the PCL/CEL blends were significantly higher than those of the neat PCL. Scanning electron microscopy (SEM) observations indicated that the CEL and the PCL were in good miscibility and there was a good adhesion at the interface of the CEL filler and the PCL matrix, suggesting that CEL could be potential filler used in PCL-based materials to reduce the cost of the friendly material, whereas increased its strength and modulus.
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Authors: Wan Jin Cho, Jun Ho Kim, Se Heang Oh, Jin Ho Lee
Abstract: Electrospinning is a fabrication process that can produce highly porous nano-scale fiber-based matrices using an electrostatically driven jet of polymer solution. This method represents an attractive approach for polymeric biomaterial processing which provides the membrane structure that may retain mechanical strengths, flexibility, and high surface area. In this study, we prepared a guided bone regeneration (GBR) membrane with selective permeability, hydrophilicity, good mechanical strength and adhesiveness with bone using polycaprolactone (PCL) and Tween 80 by the electrospinning method. The prepared PCL and PCL/Tween 80 electrospun sheets were characterized via morphology observation, mechanical property, water absorbability, and model nutrient permeability. It was observed that the PCL/Tween 80 (3 wt%) electrospun sheet have an effective permeation of nutrients as well as the good mechanical strength to maintain a secluded space for the bone regeneration. From the results, the hydrophilized PCL/Tween 80 (3 wt%) electrospun sheet seem to be a good candidate as a GBR membrane.
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Authors: Jian Fang Chen, Ai Hua Ling
Abstract: A series of novel miktoarm star polymers were synthesized by combination of at-om transfer radical polymerization(ATRP), chemical modification and ring-opening polymeri-zation(ROP). These miktoarm star polymers carring one poly[6-(4-methoxy-4’-oxy-azobenzene) hexylmethacrylate] azobenzene (PMMAZO) side-chain liquid crystalline(LC) arm and two polycaprolactone(PCL) arms. These precursors and miktoarm star polymers were characterized by proton nuclear resonance (1H-NMR), and gel permeation chramatograph(GPC). The information of PMMAZO(OH)2 and PMMAZO-(PCL)2 miktoarm star polymer confirmed the expected structure.
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Authors: Vincenzo Guarino, Antonio Gloria, Marco A. Alvarez-Perez, Maria Grazia Raucci, Valentina Cirillo, Alfredo Ronca, Roberto De Santis, Luigi Ambrosio
Abstract: In order to mimic the behaviors of natural tissue, the optimal approach for designing novel biomaterials has to be inspired to nature guidelines. One of the major challenge consists in the development of well-organized structures or scaffolds with controlled porosity in terms of pore size, pore shape and interconnection degree able to guide new tissue formation during the in vivo degradation following the scaffold implantation. Scaffolds endowed with molecular cues together to a controlled degradation profile should contribute to cell proliferation and differentiation, controlled vascularization, promoting the remodeling of neo tissue through a gradual transmission of bio-chemicals and biophysical signals as performed by the extracellular matrix (ECM). Here, different polymers and composites have been investigated to design scaffolds with peculiar micro and/or nanometric morphological features in order to satisfy all these requirements: a) bioactive scaffolds, with tailored porosity and high pores interconnectivity were developed by integrating PLA fibres, Calcium Phosphates particles or Hyaff11 phases into a Poly(ε-caprolactone) (PCL) matrix by the combination of filament winding technology and phase inversion/salt leaching technique as mineralised ECM analogue for bone regeneration; b) custom made PCL/hydroxyapatite scaffolds were designed by imaging and rapid prototyping technologies for the osteochondral defect. c) Ester of Hyaluronic Acid reinforced with degradable fibres were processed by composite technology, phase inversion and salt leaching technique, to obtain scaffolds for meniscus regeneration. d) PCL and gelatin nanofibres were obtained by highly customized fibre deposition via electrospinning to guide the nerve outgrowth in nerve regeneration. All the proposed approaches offer the chance of realizing tailor-made platforms with micro/nanoscale architecture and chemical composition suitable for the regeneration of the extracellular matrix of a large variety of natural tissues (i.e, bone, menisci, osteochondral and peripheral nervous tissues).
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