Papers by Keyword: Transfection Efficiency

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Authors: Tae Hee Kim, In Kyu Park, Su Il Kim, Hwan Jeong Jeong, Hee Seung Bom, Chong Su Cho
Abstract: Chitosan has been considered to be a good candidate for gene delivery system, since it is already known as a biocompatible, biodegradable, and low toxic material with high cationic potential. However, low specificity and low transfection efficiency of chitosan need to be overcome prior to clinical trial. In this review paper, chemical modification of chitosan for enhancement of cell specificity and transfection efficiency was explained. Also, chemical modification of chitosan for the stability of chitosan/DNA complexes was reviewed.
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Authors: Tae Hee Kim, Jin Hua, Hyun Woo Kim, Myung Haing Cho, Jae Woon Nah, Yun Jaie Choi, Chong Su Cho
Abstract: The development of an efficient targeted gene delivery system into cells is an important strategy for the advancement of gene therapy. The targeted gene delivery system is especially important in non-viral gene transfer which shows the relative low transfection efficiency. And it also opens the possibility of selective delivery of therapeutic plasmids to specific tissues. Chitosan has been considered to be a good candidate for gene delivery system, since it is already known as a biocompatible, biodegradable, and low toxic material with high cationic potential. However, low specificity and low transfection efficiency of chitosan need to be overcome prior to clinical trial. In this study, we focused on the chemical modification of chitosan for enhancement of cell specificity and transfection efficiency.
641
Authors: Tae Hee Kim, Hua Jin, Hyun Woo Kim, Myung Haing Cho, Jae Woon Nah, Chong Su Cho
Abstract: The key strategy for the advancement of gene therapy is the development of an efficient targeted gene delivery system into cells. The targeted gene delivery system is especially important in non-viral gene transfer which shows the relatively low transfection efficiency. It also opens the possibility of selective delivery of therapeutic plasmids to specific tissues. Chitosan has been considered to be a good candidate for gene delivery system, since it is already known as a biocompatible, biodegradable, and low toxic material with high cationic potential. However, low specificity and low transfection efficiency of chitosan need to be overcome prior to clinical trial. In this study, we focused on the chemical modification of chitosan for enhancement of cell specificity and transfection efficiency. Also, the potential of clinical application was investigated.
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